Results 81 to 90 of about 1,391,444 (333)

Australia and the Non-Proliferation and Disarmament Initiative: difficult times for disarmament diplomacy [PDF]

Australia recognises the critical role that the Treaty on the Non-Proliferation of Nuclear Weapons plays in preventing uncontrolled proliferation and promoting disarmament, and upholding the treaty has long been a core foreign policy goal.
Tanya Ogilvie-White
core  

EU Foreign Policy Identity: A Case Study on the EU’s Engagement of the Islamic Republic of Iran. College of Europe EU Diplomacy Paper 06/2019 [PDF]

, 2019
The Joint Comprehensive Plan of Action (JCPOA) is often referred to as the biggest foreign policy success of the European Union (EU). It ended twelve years of tough negotiations, stabilising one of the most volatile regions of the world.
McCloskey-Gholikhany, Leah
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The global nuclear order and the crisis of the nuclear non-proliferation regime: Taking stock and moving forward. [PDF]

Z Friedens Konfliktforsch, 2021
Baldus J, Müller H, Wunderlich C.
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

WDR79 mediates the proliferation of non‐small cell lung cancer cells by regulating the stability of UHRF1 [PDF]

, 2018
Jieying Chen, Xunan Sheng, Hongchang Ma, Zhengshan Tang, Chao Yang, Lanqin Cao, Yang Sun, Tanggang Deng, Peifu Feng, Bin Hu, Dong Wei, Jing Liu, Wei Xiong, Mao Ye   +13 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Iran's nuclear ambitions and the new world order [PDF]

, 2004
No abstract ...
Mather, Y.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The GIBACHT fellowship: a multilateral initiative for strengthening capacity in biosafety and biosecurity towards pandemic preparedness

Frontiers in Public Health
The German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or the intentional misuse of highly pathogenic agents. As part of this programme, this paper describes
Eva Mertens, Eva Mertens, Marlow Zimmermann, Marlow Zimmermann, Janine Dywicki, Janine Dywicki, Min-Hi Lee, Min-Hi Lee, Joachim Pelikan, Joachim Pelikan, Joachim Pelikan, Barbara M. Bürkin, Barbara M. Bürkin, Barbara M. Bürkin, Elizeus Rutebemberwa, Elizeus Rutebemberwa, Axel Hoffmann, Axel Hoffmann, Axel Hoffmann   +18 more
doaj   +1 more source