Results 111 to 120 of about 359,465 (284)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Futility monitoring for randomized clinical trials with non-proportional hazards: An optimal conditional power approach. [PDF]
Clin Trials, 2023 Wang X, George SL.
europepmc +1 more source
Stratified-extended cox model in survival modeling of non-proportional hazard
IOP Conference Series: Earth and Environmental Science, 2019 AbstractCox proportional hazard model is frequently used in survival analysis. Cox proportional hazard model is time independent covariate while many models involve time as a dependent covariate causing incomplete proportional hazard assumption, known as non-proportional hazard.
D J Ratnaningsih +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The incidence risk of type 2 diabetes mellitus in female nurses: a nationwide matched cohort study
BMC Public Health, 2016 Background Diabetes is one of the most common chronic illnesses worldwide. This study was to assess whether the incidence risk of type 2 diabetes mellitus between female nurses and female non-nurses. Methods Study data were obtained from the Longitudinal
Hsiu-Ling Huang +5 more
doaj +1 more source
Investigating non-inferiority or equivalence in time-to-event data under non-proportional hazards. [PDF]
Lifetime Data Anal, 2023 Möllenhoff K, Tresch A.
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Clinical effectiveness reporting of novel cancer drugs in the context of non-proportional hazards: a review of nice single technology appraisals. [PDF]
Int J Technol Assess Health Care, 2023 Salmon D, Melendez-Torres GJ.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source