Results 31 to 40 of about 617,984 (298)

The Hazard of Non-proportional Hazards in Time to Event Analysis.

open access: yesEuropean Journal of Vascular and Endovascular Surgery, 2021
L. Meuli, C. Kuemmerli
semanticscholar   +4 more sources

Estimating average regression effect under non-proportional hazards. [PDF]

open access: yesBiostatistics, 2000
We present an estimator of average regression effect under a non-proportional hazards model, where the regression effect of the covariates on the log hazard ratio changes with time. In the absence of censoring, the new estimate coincides with the usual partial likelihood estimate, both estimates being consistent for a parameter having an interpretation
R. Xu, J. O'Quigley
semanticscholar   +4 more sources

Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts

open access: yesComputational and Structural Biotechnology Journal, 2022
Background: Cox proportional hazard regression (CPH) model relies on the proportional hazard (PH) assumption: the hazard of variables is independent of time. CPH has been widely used to identify prognostic markers of the transcriptome.
Zihang Zeng   +7 more
doaj   +1 more source

Stratified-extended cox model in survival modeling of non-proportional hazard [PDF]

open access: diamondIOP Conference Series: Earth and Environmental Science, 2019
AbstractCox proportional hazard model is frequently used in survival analysis. Cox proportional hazard model is time independent covariate while many models involve time as a dependent covariate causing incomplete proportional hazard assumption, known as non-proportional hazard.
Dewi Juliah Ratnaningsih   +3 more
openalex   +2 more sources

Extensions of cox model for non-proportional hazards purpose [PDF]

open access: yesEkonometria, 2014
Cox proportional hazard model is one of the most common methods used in analysis of time to event data. The idea of the model is to define hazard level as a dependent variable which is being explained by the time-related component (so called baseline hazard) and covariates-related component.
J. Borucka
semanticscholar   +2 more sources

Simulating time-to-event data under the Cox proportional hazards model: assessing the performance of the non-parametric Flexible Hazards Method

open access: yesFrontiers in Applied Mathematics and Statistics, 2023
Numerous methods and approaches have been developed for generating time-to-event data from the Cox Proportional Hazards (CPH) model; however, they often require specification of a parametric distribution for the baseline hazard even though the CPH model ...
Jennifer L. Delzeit, Devin C. Koestler
doaj   +1 more source

CauchyCP: A powerful test under non-proportional hazards using Cauchy combination of change-point Cox regressions [PDF]

open access: yesStatistical Methods in Medical Research, 2020
Non-proportional hazards data are routinely encountered in randomized clinical trials. In such cases, classic Cox proportional hazards model can suffer from severe power loss, with difficulty in interpretation of the estimated hazard ratio since the ...
Hong Zhang   +3 more
semanticscholar   +1 more source

Statistical Considerations for Evaluating Treatment Effect under Various Non-proportional Hazard Scenarios [PDF]

open access: greenStatistical Methods in Medical Research
We conducted a systematic comparison of statistical methods used for the analysis of time-to-event outcomes under various proportional and non-proportional hazard (NPH) scenarios. Our study used data from recently published oncology trials to compare the Log-rank test, still by far the most widely used option, against some available alternatives ...
Xinyu Zhang   +3 more
openalex   +4 more sources

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