Results 41 to 50 of about 382,729 (291)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Seismic cycles, size of the largest events, and the avalanche size distribution in a model of seismicity [PDF]

, 2012
We address several questions on the behavior of a numerical model recently introduced to study seismic phenomena, that includes relaxation in the plates as a key ingredient.
A. Rosso, E. A. Jagla, H. Scholz, L. E. Aragón, R. Burridge   +4 more
core   +2 more sources

Fatigue strength of welded joints under multiaxial non-proportional loading

Procedia Structural Integrity, 2017
Abstract Fatigue behaviour of a fillet-welded tubular T-joint in the so-called H structural component of an agricultural sprayer is examined by using experimental strain measurements found in the literature and linear elastic finite element analyses.
Sabrina Vantadori, Joel Boarettob, Giovanni Fortese, Felipe Giordani, Roberto Isoppo Rodrigues, Ignacio Iturrioz, Camilla Ronchei, Daniela Scorza, Andrea Zanichelli   +8 more
openaire   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A new multiaxial fatigue life prediction model considering additional hardening effect

Advances in Mechanical Engineering, 2020
The established linear fatigue life prediction model based on the Miner rule has been widely applied to fatigue life prediction under constant amplitude uniaxial and multiaxial loading.
Li Bin, Liu Jianhui, Wang Xiuli
doaj   +1 more source

Influence of notch sensitivity and crack initiation site on low cycle fatigue life of notched components under multiaxial non-proportional loading [PDF]

Fracture and Structural Integrity, 2019
A series of strain controlled multiaxial low cycle fatigue (LCF) tests under proportional and non-proportional loading conditions have been conducted on notched specimens. Cylindrical bars of Al 6061 aluminum alloy and AISI 316L stainless steel with four
Stefano Bressan, Fumio Ogawa, Takamoto Itoh, Filippo Berto   +3 more
doaj   +1 more source

Fatigue Life Assessment of Metals under Multiaxial Asynchronous Loading by Means of the Refined Equivalent Deformation Criterion

Metals, 2023
As is well-known, non-proportional fatigue loading, such as asynchronous one, can have significant detrimental effects on the fatigue behavior of metallic materials by reducing the fatigue strength/fatigue limit and by leading to a fatigue damage ...
Daniela Scorza
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Ductile damage evolution under cyclic non-proportional loading paths

Procedia Structural Integrity, 2018
Abstract The characterization of ductile damage evolution, and its description, have been the object of extensive research in the continuum damage mechanic field. Starting from the pioneering works of Lemaitre (1985), Gurson (1977), Rousselier (1987), many different models have been developed.
Fincato R, Tsutsumi S, Momii H
openaire   +2 more sources

Bending and Torsion Fatigue-Testing Machine Developed for Multiaxial Non-Proportional Loading

Metals, 2019
A new fatigue-testing machine was developed to perform high-cycle multiaxial fatigue tests at 50 Hz, in order to reduce testing time. The developed machine can combine bending and torsion loading and perform fatigue tests at a high frequency, under ...
Fumio Ogawa, Yusuke Shimizu, Stefano Bressan, Takahiro Morishita, Takamoto Itoh   +4 more
doaj   +1 more source