Results 61 to 70 of about 147,595 (279)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multiaxial Low Cycle Fatigue of 1070Aluminum under Stress Controlled Non-proportional Loading [PDF]

, 2007
This paper describes the low cycle fatigue life of 1070 aluminum under stress controlled multiaxial loading. Proportional loading tests were carried out under combined push-pull and reversed torsion.
伊藤, 隆基, HIRAI, Takanori, 平井, 孝典, 山本, 隆栄, YAMAMOTO, Takaei, ITO, Takamoto   +5 more
core   +1 more source

Biaxial Testing of Thin Metal Sheets under Non-Proportional Loading Conditions

Metals
During the manufacturing and service of thin metal sheets, different stress states occur, often caused by non-proportional loading conditions. They can lead to localization of inelastic deformations as well as to damage and failure processes.
Steffen Gerke, Fabuer R. Valencia, Michael Brünig   +2 more
doaj   +1 more source

Taking into account the non-proportional loading effect on high cycle fatigue life predictions obtained by invariant-based approaches [PDF]

MATEC Web of Conferences, 2019
Industrial structures are often subjected to multiaxial fatigue loadings. If the multiple stress signals are not synced the loading is said to be non-proportional.
Bercelli Lorenzo, Doudard Cédric, Moyne Sylvain   +2 more
doaj   +1 more source

Semi – automatic approach for the creation of non - proportional load paths

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Many industrial sheet metal parts experience a non – proportional loading history. The determination of such non – proportional loading paths on a laboratory scale is still very challenging and time - consuming. Most tests require different machines, tools and measurement techniques.
R. Norz, W. Volk
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Modeling of crack propagation in ductile materials under cyclic, proportional and non-proportional loading conditions

The paper addresses the numerical calculation of multi-axial fatigue crack propagation in ductile materials under proportional and non-proportional cyclic loading conditions. The analysis is based on a phase field fracture theory proposed in earlier work,
Tsakmakis, Aris, Gibb, Alwin, Vormwald, Michael   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source