Results 61 to 70 of about 382,729 (291)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Fatigue life estimation in welded joints under multiaxial loadings [PDF]
, 2009 Welded joints are frequently locations for cracks initiation and propagation that may cause fatigue failure of engineering structures. Biaxial or triaxial stress-strain states are present in the vicinity of welded joints, due to local geometrical ...
Carpinteri, Andrea +2 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Study of Experimental Hysteresis Loops Under Non-Proportional Loading
Engineer: Journal of the Institution of Engineers, Sri Lanka, 2021 Fatigue life prediction is a challenge for engineers when it comes under nonproportionalloading. In many applications, engineering components are subjected to complicated states of stress and strain. Studying of hysteresis behavior under non proportional loading is important for reliable engineering designing for studying the cyclic deformation that is
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Non‐proportional loading in sequentially linear analysis for 3D stress states [PDF]
International Journal for Numerical Methods in Engineering, 2019 SummarySequentially linear analysis (SLA), a non‐incremental‐iterative approach towards finite element simulation of quasi‐brittle materials, is based on sequentially identifying a critical integration point in the model, to reduce its strength and stiffness, and the associated critical load multiplier (λcrit), to scale the linear analysis results.
Manimaran Pari +2 more
openaire +4 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2020 In a pressure vessel, a heat exchanger and a junction piping where cold and hot water are mixed, temperature fluctuation yields multiaxial stress and random amplitude loading conditions.
Takahiro MORISHITA +2 more
doaj +1 more source
Non-proportional deformation paths for sheet metal: experiments and models [PDF]
, 2009 For mild steel, after significant plastic deformation in one direction, a subsequent deformation in an orthogonal direction shows a typical stress overshoot compared to monotonic deformation. This phenomenon is investigated experimentally and numerically
Boogaard, A.H. van den, Riel, M. van
core +2 more sources
Material modelling and springback analysis for multi-stage rotary draw bending of thin-walled tube using homogeneous anisotropic hardening model [PDF]
The aim of this paper is to compare several hardening models and to show their relevance for the prediction of springback and deformation of an asymmetric aluminium alloy tube in multi-stage rotary draw bending process. A three-dimensional finite-element
Barlat, F, Gracio, J, Liao, J, Xue, X
core +1 more source