Results 81 to 90 of about 382,729 (291)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Biaxial Testing of Thin Metal Sheets under Non-Proportional Loading Conditions

Metals
During the manufacturing and service of thin metal sheets, different stress states occur, often caused by non-proportional loading conditions. They can lead to localization of inelastic deformations as well as to damage and failure processes.
Steffen Gerke, Fabuer R. Valencia, Michael Brünig   +2 more
doaj   +1 more source

Microscopic origin of granular ratcheting

, 2007
Numerical simulations of assemblies of grains under cyclic loading exhibit ``granular ratcheting'': a small net deformation occurs with each cycle, leading to a linear accumulation of deformation with cycle number.
G. Festag, H. Goldstein, H. J. Herrmann, P. A. Cundall, R. García-Rojo, R. García-Rojo, S. Luding, S. McNamara   +7 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A thermodynamically consistent cohesive damage model for the simulation of mixed-mode delamination [PDF]

, 2017
This work is devoted to the formulation of a new cohesive model for mixed-mode delamination. The model is based on a thermodynamically consistent isotropic damage formulation, with consideration of an internal friction mechanism that governs
Confalonieri, Federica, Perego, Umberto
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Creep fatigue life prediction for engine hot section materials (isotropic) [PDF]

A series of high temperature strain controlled fatigue tests have been completed to study the effects of thermomechanical fatigue, multiaxial loading, reactive environments, and imposed mean stresses. The baseline alloy used in these tests was cast B1900+
Levan, G. W., Nelson, R. S., Schoendorf, J. F.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The moment of inertia method to calculate equivalent ranges in non-proportional tension–torsion histories

Journal of Materials Research and Technology, 2015
A critical issue in multiaxial damage calculation in non-proportional (NP) histories is to find the equivalent stress or strain ranges and mean components associated with each rainflow-counted cycle of the stress (or strain) path.
Marco Antonio Meggiolaro, Jaime Tupiassú Pinho de Castro   +1 more
doaj   +1 more source

Finite element analysis of fretting crack propagation

, 2011
In this work, the finite elements method (FEM) is used to analyse the growth of fretting cracks. FEM can be favourably used to extract the stress intensity factors in mixed mode, a typical situation for cracks growing in the vicinity of a fretting ...
Basseville, Stéphanie, Proudhon, Henry
core   +3 more sources