Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]
, 2011 Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M. +2 more
core +1 more source
Prognostic significance of folate metabolism polymorphisms for lung cancer. [PDF]
, 2007 Functional nonsynonymous single-nucleotide polymorphisms (nsSNPs) of folate metabolism genes can influence the methylation of tumour suppressor genes, thereby potentially impacting on tumour behaviour.
El Galta, R +13 more
core +1 more source
Gemcitabine plus carboplatin versus mitomycin, ifosfamide, and cisplatin in patients with stage IIIB or IV non-small-cell lung cancer: a phase III randomized study of the London Lung Cancer Group [PDF]
, 2005 Purpose: This phase III randomized trial compared two chemotherapy regimens, gemcitabine plus carboplatin and mitomycin, ifosfamide, and cisplatin, in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC).
Harper, P.G. +25 more
core +1 more source
The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]
, 2010 <b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Meek, C.L. +3 more
core +1 more source
CD133 and non-small-cell lung cancer [PDF]
European Journal of Cardio-Thoracic Surgery, 2010 The striking prevalence in women is well documented since many years, with about 80—90% clearly resulting from the smaller dimensions of the airways in women (see also the comment by Sameh Sensar in ICVTS 3(2004) 404). Thus, there is no consensus about the treatment modalities, but there is an explicit trend to conservative treatment since one of the ...
openaire +2 more sources
Regulation of Mitochondria-dependent Apoptosis in Non-Small Cell Lung Cancer: Implications for Cancer Therapy [PDF]
, 2007 Summary The work described in this thesis focuses on the characterization of the mechanism(s) underlying the deregulated activation of the intrinsic or mitochondrial apoptotic pathway in non-small cell lung cancer (NSCLC) cells.
Checinska, A.
core
Chemotherapy in non-small cell lung cancer
Annals of Oncology, 1995 Non-small cell lung cancer can no longer be regarded as resistant to chemotherapy, and there have recently been considerable improvements in the use of the older agents and advances in the identification of new drugs. Recent meta-analysis has also confirmed the view that chemotherapy can have small but modest survival benefits.
N, Thatcher +4 more
openaire +2 more sources
Quality of life in patients receiving platinum based chemotherapy for advanced non-small cell lung cancer. [PDF]
, 2006 Quality of life in patients receiving platinum based chemotherapy for advanced non-small cell lung cancer. Lung cancer is the cause of 34,000 deaths in the UK each year, with a five year survival rate of only 7.5%.
Leary, A.
core
Development of taxane resistance in a panel of human lung cancer cell lines [PDF]
, 2008 Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne +3 more
core +2 more sources
How to manage KRAS G12C-mutated advanced non-small-cell lung cancer
Drugs in Context, 2022 Constitutive KRAS signalling drives tumorigenesis across several cancer types. In non-small-cell lung cancer (NSCLC) activating KRAS mutations occur in ~30% of cases, and the glycine to cysteine substitution at codon 12 (G12C) is the most common KRAS ...
Biagio Ricciuti +10 more
doaj +1 more source