Results 41 to 50 of about 385 (111)

Do childhood vaccines have non-specific effects on mortality?

Bulletin of the World Health Organization, 2003
A recent article by Kristensen et al. suggested that measles vaccine and bacille Calmette-Gu rin (BCG) vaccine might reduce mortality beyond what is expected simply from protection against measles and tuberculosis. Previous reviews of the potential effects of childhood vaccines on mortality have not considered methodological features of reviewed ...
Cooper, O. William, Boyce , G. Thomas, Wright, F. Peter, Griffin, R. Martin   +3 more
openaire   +5 more sources

Developing the concept of beneficial non-specific effect of live vaccines with epidemiological studies [PDF]

Clinical Microbiology and Infection, 2019
Epidemiological and immunological studies are increasingly reporting non-specific effects (NSEs) of vaccines; i.e. vaccines may affect the risk and severity of non-targeted infections. We reviewed how epidemiological studies developed the concept of beneficial NSEs of live vaccines.This is a personal narrative of how we came to pursue the concept of ...
Aaby, P., Benn, C. S.
openaire   +5 more sources

Sex-differential non-specific effects of adjuvanted and non-adjuvanted rabies vaccines versus placebo on all-cause mortality in dogs (NERVE-Dog study): a study protocol for a randomized controlled trial with a nested case–control study

BMC Veterinary Research, 2022
Background It has been proposed that childhood vaccines in high-mortality populations may have substantial impacts on mortality rates that are not explained by the prevention of targeted diseases, nor conversely by typical expected adverse reactions to ...
Darryn L. Knobel, Anne Conan, Felix N. Toka, Sintayehu M. Arega, Charles Byaruhanga, Eric Ogola, Erick M. O. Muok, Jan E. Crafford, Andrew L. Leisewitz, Melvyn Quan, Mary Anna Thrall   +10 more
doaj   +1 more source

The non-specific effects of vaccines in low income countries [PDF]

Archives of Disease in Childhood, 2010
In their commentary on my article about the non-specific effects of vaccines, Paul Fine and David Elliman state that we are dealing with ‘unproven non-specific effects’ and imply that these effects may not be of widespread importance because ‘much of the evidence’ comes from Guinea-Bissau.1 First, proof is never possible in medicine.
openaire   +2 more sources

Co-administration of BCG and Diphtheria-tetanus-pertussis (DTP) Vaccinations May Reduce Infant Mortality More Than the WHO-schedule of BCG First and Then DTP. A Re-analysis of Demographic Surveillance Data From Rural Bangladesh

EBioMedicine, 2017
Background: WHO recommends BCG at birth and diphtheria-tetanus-pertussis (DTP)-containing vaccine at 6, 10 and 14 weeks of age. However, BCG and DTP are often co-administered in low-income countries.
Peter Aaby, Andreas Andersen, Henrik Ravn, K. Zaman   +3 more
doaj   +1 more source

The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment

EBioMedicine, 2017
Background: We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s.
Søren Wengel Mogensen, Andreas Andersen, Amabelia Rodrigues, Christine S Benn, Peter Aaby   +4 more
doaj   +1 more source

Evaluation of non-specific effects of human rotavirus vaccination in medical risk infants

Vaccine, 2021
The WHO recommends research into non-specific effects of vaccination. For rotavirus vaccines, these have not yet been well established. We studied non-specific effects up to 18 months of age using data from a quasi-experimental before-after study comparing cohorts of rotavirus vaccinated and unvaccinated infants with medical risk conditions.Infants ...
Marc J. M. Bonten, Josephine A P van Dongen, Patricia Bruijning-Verhagen, Elsbeth D M Rouers, Rivar study team   +4 more
openaire   +3 more sources

Immunostimulation with oral vaccines for prevention and treatment of respiratory tract infections

Pediatria i Medycyna Rodzinna, 2016
The respiratory system is susceptible to unfavourable effects of biological and non-biological factors. In the protection against infectious agents, the immune system plays a crucial role thanks to close cooperation of specific (acquired) and non ...
Robert Szamborski
doaj   +1 more source

Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects

Vaccines, 2022
Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic
Madhu Gupta, Abhishek Wahi, Priyanka Sharma, Riya Nagpal, Neha Raina, Monika Kaurav, Jaydeep Bhattacharya, Sonia M. Rodrigues Oliveira, Karma G. Dolma, Alok K. Paul, Maria de Lourdes Pereira, Polrat Wilairatana, Mohammed Rahmatullah, Veeranoot Nissapatorn   +13 more
doaj   +1 more source

Contradictory mortality results in early 2-dose measles vaccine trials: interactions with oral polio vaccine may explain differences

International Journal of Infectious Diseases
Objectives: Between 2003 and 2019, three trials (randomised controlled trials [RCTs]) in Guinea-Bissau randomised infants to an early 2-dose measles vaccine (MV) schedule at 4 and 9 months vs standard MV at 9 months.
Sebastian Nielsen, Ane B. Fisker, Ali Sie, Olaf Müller, Eric Nebie, Heiko Becher, Fiona van der Klis, Sofie Biering-Sørensen, Stine Byberg, Sanne M. Thysen, Isaquel da Silva, Amabelia Rodrigues, Cesario Martins, Hilton C. Whittle, Peter Aaby, Christine S. Benn   +15 more
doaj   +1 more source