Results 131 to 140 of about 213,082 (269)

Lichenoid dysplasia treated by apremilast - report of two cases and review of literature

Journal of Family Medicine and Primary Care
Lichenoid dysplasia (LD) is a distinct clinicopathologic condition characterized by bilateral or unilateral oral lesions with a lichenoid pattern and atypical cells, giving it a higher risk for malignant transformation. Unlike oral lichen planus (OLP) or
Shiladitya Sil, Rudra Pyne, Sayani Shome, Soumyajit Dutta   +3 more
doaj   +1 more source

`Non-steroidals' [PDF]

Gut, 1996
openaire   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

Advanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang, Hailin Shang, Ling Jiao, Ce Chen, Zehua Liu, Yi Yang, Qiannan Zhang, Song Tang, Xudong Jia, Hui Yang, Yi Wan   +10 more
wiley   +1 more source

Risk Factors of Nonsteroidal Anti-inflammatory Drug-exacerbated Respiratory Disease: A Systematic Review and Meta-analysis of Observational Studies

Oman Medical Journal
Objectives: This meta-analysis aimed to identify the risk factors associated with nonsteroidal anti-inflammatory drug -exacerbated respiratory disease (NERD), a chronic eosinophilic, inflammatory respiratory disorder characterized by hypersensitivity to ...
Edwin Nugroho Njoto, Moon Fai Chan, Anak Agung Bagus Wirayuda, Gumilar Fardhani Ami Putra, Desiana Widityaning Sari, Endah Indriastuti, Rizka Nurul Hidayah, Yuri Pamungkas, Edith Maria Djaputra   +8 more
doaj   +1 more source

Non-Steroidal Antioestrogens [PDF]

British Journal of Cancer, 1983
openaire   +1 more source

The content of general practice in Malta : a pilot study comparing health centre and private practice in Malta with each other and with general practice (as reported for other countries) [PDF]

, 1989
The effective planning of a system and the training of personnel to run it requires accurate data regarding the use to be made of the system. For a health care system such data, apart from actual numbers of patients, will include age/sex distribution ...
Agius Muscat, Hugo, Carabott, Paul
core  

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

The Impact of Differential Cost Sharing of Non-Steroidal Anti-Inflammatory Agents on the Use and Costs of Analgesic Drugs [PDF]

OBJECTIVE: To estimate the effect of differential cost sharing (DCS) schemes for non-steroidal anti-inflammatory drugs (NSAIDs) on drug subsidy program and beneficiary expenditures.
Adrian R. Levy, Anne M. Holbrook, Bernie J. O'Brien, John K. Marshall, Lisa R. Dolovich, Paul V. Grootendorst   +5 more
core  

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source