Results 101 to 110 of about 42,828,722 (241)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Local structural flexibility drives oligomorphism in computationally designed protein assemblies [PDF]

Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. For example, clathrin coats adopt a wide variety of architectures to adapt to vesicular cargos of various sizes.
Veesler, David, Bethel, Neville P, Antanasijevic, Aleksandar, King, Neil P., King, Neil P, Twarock, Reidun, Watkins, Andrew M, Borst, Andrew J, Miranda, Marcos C, Watkins, Andrew M., Lai, Szu-Hsueh, Wu, Mengyu, Fatehi, Farzad, Baker, David, Wang, Jing Yang 'John', Heck, Albert J R, Borst, Andrew J., Khmelinskaia, Alena, Ward, Andrew B, Ogohara, Cassandra, Chim, Ho Yeung, Wang, Jing Yang (John), Bethel, Neville P., Mallik, Bhoomika Basu, Miranda, Marcos C., Heck, Albert J.R., Caldwell, Shane, Ward, Andrew B.   +27 more
core   +1 more source

Non-structural protein 1 and hematology parameters as predictors of dengue virus infection severity in Indonesia. [PDF]

J Med Life, 2023
Sunari IGAAEP, Aryati A, Hakim FKN, Tanzilia MF, Zuroidah N, Wrahatnala BJ, Rohman A, Wardhani P, Husada D, Miftahussurur M.   +9 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural and binding studies of SAP-1 protein with heparin.

, 2014
SAP-1 is a low molecular weight cysteine protease inhibitor (CPI) which belongs to type-2 cystatins family. SAP-1 protein purified from human seminal plasma (HuSP) has been shown to inhibit cysteine and serine proteases and exhibit interesting biological
Yadav, V.
core   +1 more source

An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by β-coronavirus Non-structural Protein 1. [PDF]

J Mol Biol, 2023
Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, Vögeli B, Kieft JS, Glasgow A, Steckelberg AL.   +10 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Structural characterisation of pre-processed thermoplastic protein derived from bloodmeal [PDF]

, 2012
Additives are required to convert bloodmeal powder into an extrudable thermoplastic protein-based bioplastic. These include a protein denaturant, a surfactant, a reducing agent and plasticisers.
Verbeek, Casparus Johan R., Lay, Mark C., Bier, James Michael   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Unbiased Identification of Dengue Virus Non-Structural Protein 1 Peptides for Use in Vaccine Design. [PDF]

Vaccines (Basel), 2022
Warner NL, Core SB, Frietze KM.
europepmc   +1 more source