Results 121 to 130 of about 6,567,287 (293)

A protocol for wide-scope non-target analysis of contaminants in small amounts of biota using bead beating tissuelyser extraction and LC-HRMS. [PDF]

MethodsX, 2021
Gil-Solsona R, Rodriguez-Mozaz S, Diaz-Cruz MS, Sunyer-Caldú A, Luarte T, Höfer J, Galbán-Malagón C, Gago-Ferrero P.   +7 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Non-target screening analysis of hazardous noxious substances using gas chromatography-quadrupole time-of-flight mass spectrometry

Environmental Advances
The forensic investigation of hazardous noxious substances (HNS) is paramount for an effective response to chemical spill emergencies and other accidents. Analyzing unknown emergency samples poses a challenge due to the limited availability of background
Chun Yang, Gong Zhang, Keval Shah, Lauren Brown, Zeyu Yang, Bruce Hollebone, Patrick Lambert, Vanessa Beaulac   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inventory of aqueous and sediment-associated organic pollutants released by the 2021 flood in the Vicht–Inde catchment, Germany

Environmental Sciences Europe
Background The European flood that occurred between July 13th and 16th 2021, was a natural disaster that caused significant damage in Central European countries, including Germany, Netherlands, Belgium, and Luxembourg.
Piero Bellanova, Jan Schwarzbauer, Klaus Reicherter   +2 more
doaj   +1 more source

A Fiber Optical Sensor For Non-Contact Vibration Measurements [PDF]

, 2009
This paper describes an intensity based optical sensor for the evaluation of accelerations from non-contact displacement measurements. Plastic optical fibers are used to collect the reflected light from several points on the vibrating surface, allowing ...
Casalicchio, Maria Luisa, Perrone, Guido, Vallan, Alberto   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Target and non-target screening for the existence, ecological risk and source analysis of contaminants of emerging concern (CECs) in groundwater

Environmental Chemistry and Ecotoxicology
Contaminants of emerging concern (CECs) are increasingly being discharged into the groundwater environment worldwide, causing a significant threat to human health and the environment.
Kai Liu, Jinrong Qiu, Chih-Huang Weng, Junshi Tao, Zhongen Tang, Jingwen Zeng, Na Liu, Xiujuan Wang   +7 more
doaj   +1 more source