Results 131 to 140 of about 34,491,299 (291)

Integrating non-target analysis and machine learning: a framework for contaminant source identification

npj Clean Water
Machine learning-based non-target analysis (ML-based NTA) faces the critical challenge of linking complex chemical signals to contamination sources. This review proposes a systematic framework of ML-assisted NTA for contaminant source identification ...
Peng Liu, Ding Pan, Xin-Yi Jiao, Ji-Ning Liu, Peng-Hui Du, Peng-Cheng Li, Meng-Zhu Xue, Yan-Chao Jin, Cai-Shan Wang, Xue-Rong Wang, Ying-Zhi Ding, Guang-Ning Zhu, Jing-Hao Yang, Wen-Ze Wu, Lu-Feng Liang, Xin-Hui Liu, Li-Ping Li   +16 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A functional metabolomics platform based on non-target and target chromatography-mass spectrometry

, 2011
A functional metabolomics platform based on non-target and target chromatography-mass ...
陈世礼, 许国旺, 王晓琳, 赵欣捷, 李佳, 胡春秀   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Does diabetes affect the incidence of non-target lesion revascularization? A meta-analysis of data from randomized controlled trials

BMC Endocrine Disorders
Objective This meta-analysis aimed to specifically investigate whether diabetes mellitus increases the risk of non-target lesion revascularization (NTLR) following percutaneous coronary intervention (PCI), and to assess whether glycemic control and ...
Yi Ji, Jiaxin Zhou, Zhen Lian, Binbing Shi, Yanqing Pan, Yuan Yin, Jie Liu, Guoping Zhao, Changxi Zhang, Hong Zhu, Defeng Pan   +10 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Glyphosate and Aminomethylphosphonic Acid: A Map of the Bibliography on Ecotoxicology, Fate, and Monitoring Frontier Studies in Environmental Research

Ecologies
Glyphosate is one of the most widely used herbicides worldwide, and its extensive application has raised increasing concern regarding environmental occurrence, ecological exposure, and potential risks to non-target organisms.
Jingchun Sun, Canying Zhang, Linbing Zhang, David Gonçalves, Shaoping Kuang, Hongsheng Yang   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Non-target screening analysis of hazardous noxious substances using gas chromatography-quadrupole time-of-flight mass spectrometry

Environmental Advances
The forensic investigation of hazardous noxious substances (HNS) is paramount for an effective response to chemical spill emergencies and other accidents. Analyzing unknown emergency samples poses a challenge due to the limited availability of background
Chun Yang, Gong Zhang, Keval Shah, Lauren Brown, Zeyu Yang, Bruce Hollebone, Patrick Lambert, Vanessa Beaulac   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source