Results 1 to 10 of about 17,412 (233)

Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures

Environment International, 2021
Challenges in the assessment of the health effects of the exposome, defined as encompassing all environmental exposures from the prenatal period onwards, include a possibly high rate of false positive signals.
Solène Cadiou, Xavier Basagaña, Juan R. Gonzalez, Johanna Lepeule, Martine Vrijheid, Valérie Siroux, Rémy Slama   +6 more
doaj   +1 more source

An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction

Scientific Reports, 2021
Complementary to the genome, the concept of exposome has been proposed to capture the totality of human environmental exposures. While there has been some recent progress on the construction of the exposome, few tools exist that can integrate the genome ...
Xuan Zhou, S. Hong Lee
doaj   +1 more source

Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research

Environment International, 2023
Outcome-wide analysis can offer several benefits, including increased power to detect weak signals and the ability to identify exposures with multiple effects on health, which may be good targets for preventive measures.
Augusto Anguita-Ruiz, Ines Amine, Nikos Stratakis, Lea Maitre, Jordi Julvez, Jose Urquiza, Chongliang Luo, Mark Nieuwenhuijsen, Cathrine Thomsen, Regina Grazuleviciene, Barbara Heude, Rosemary McEachan, Marina Vafeiadi, Leda Chatzi, John Wright, Tiffany C. Yang, Rémy Slama, Valérie Siroux, Martine Vrijheid, Xavier Basagaña   +19 more
doaj   +1 more source

Environmental chemical exposures and breast cancer [PDF]

, 2016
As a hormone-sensitive condition with no single identifiable cause, breast cancer is a major health problem. It is characterized by a wide range of contributing factors and exposures occurring in different combinations and strengths across a lifetime ...
Plant, J, Stanley, E, Voulvoulis, N
core   +5 more sources

Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis

Environment International, 2021
Background: Polychlorinated biphenyls (PCBs) are a large family of man-made organic, ubiquitous, and persistent contaminants with endocrine-disrupting properties.
Thibault Fiolet, Yahya Mahamat-Saleh, Pauline Frenoy, Marina Kvaskoff, Francesca Romana Mancini   +4 more
doaj   +1 more source

Application of two statistical approaches (Bayesian Kernel Machine Regression and Principal Component Regression) to assess breast cancer risk in association to exposure to mixtures of brominated flame retardants and per- and polyfluorinated alkylated substances in the E3N cohort

Environmental Health, 2022
Background Brominated flame retardants (BFR) and per- and polyfluorinated alkylated substances (PFAS) are two groups of substances suspected to act as endocrine disruptors. Such substances could therefore be implicated in the occurrence of breast cancer,
Pauline Frenoy, Vittorio Perduca, German Cano-Sancho, Jean-Philippe Antignac, Gianluca Severi, Francesca Romana Mancini   +5 more
doaj   +1 more source

Merging the exposome into an integrated framework for “omics” sciences

iScience, 2022
Summary: The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual’s health over their life course.
Elliott J. Price, Chiara M. Vitale, Gary W. Miller, Arthur David, Robert Barouki, Karine Audouze, Douglas I. Walker, Jean-Philippe Antignac, Xavier Coumoul, Vincent Bessonneau, Jana Klánová   +10 more
doaj   +1 more source

The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies [PDF]

, 2018
Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental
Cano Sancho, German, Marín Sillué, Sònia, Ramos Girona, Antonio J., Sanchís Almenar, Vicente   +3 more
core   +4 more sources

Towards Convergence: How to Do Transdisciplinary Environmental Health Disparities Research. [PDF]

, 2020
Increasingly, funders (i.e., national, public funders, such as the National Institutes of Health and National Science Foundation in the U.S.) and scholars agree that single disciplines are ill equipped to study the pressing social, health, and ...
Cannon, Clare EB
core   +1 more source

Mapping the Human Exposome to Uncover the Causes of Breast Cancer. [PDF]

, 2019
Breast cancer is an important cause of morbidity and mortality for women, yet a significant proportion of variation in individual risk is unexplained. It is reasonable to infer that unexplained breast cancer risks are caused by a myriad of exposures and ...
Bessonneau, Vincent, Rudel, Ruthann A
core   +2 more sources