Results 11 to 20 of about 15,210 (215)

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

open access: yesToxics, 2019
The proposal of the “exposome” concept represents a shift of the research paradigm in studying exposure-disease relationships from an isolated and partial way to a systematic and agnostic approach.
Chih-Wei Liu, Yunjia Lai, Jingchuan Xue
exaly   +4 more sources

Relevance and challenges of exposome studies for environmental health research [PDF]

open access: yesEnvironmental Health
The exposome encompasses all environmental exposures humans undergo from conception. We frame exposome studies according to four broad aims essential for environmental health research.
Rémy Slama   +3 more
doaj   +3 more sources

The early-life exposome: Description and patterns in six European countries [PDF]

open access: yesEnvironment International, 2019
Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases.Here, we aimed to describe the early ...
Montserrat de Castro Pascual   +2 more
exaly   +4 more sources

Charting the landscape of the environmental exposome

open access: yesiMeta, 2022
The exposome depicts the total exposures in the lifetime of an organism. Human exposome comprises exposures from environmental and humanistic sources. Biological, chemical, and physical environmental exposures pose potential health threats, especially to
Chao Jiang, Xin Wei, Liuyiqi Jiang
exaly   +2 more sources

Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts. [PDF]

open access: yesAlzheimers Dement
Abstract External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer's disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential ...
Popp Z   +9 more
europepmc   +2 more sources

The Alcohol Exposome [PDF]

open access: yesAlcohol
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-
Sabet, Nousha H, Wyatt, Todd A.
core   +3 more sources

Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index

open access: yesEnvironment International, 2020
Background: The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate ...
Eleni Papadopoulou   +2 more
exaly   +3 more sources

The skin aging exposome [PDF]

open access: yesJournal of Dermatological Science, 2016
The term “exposome” describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body’s response to these factors.
Sore, Gabrielle   +4 more
core   +4 more sources

An evolutionary perspective for the exposome

open access: yesExposome
The exposome was proposed following the realization that most human diseases have an environmental rather than a genetic (hereditary) origin. Non-communicable diseases are, in fact, the consequence of multiple exposures that activate a sequence of stages
Vineis, Paolo, Dagnino, Sonia
core   +3 more sources

Update of the human early life exposome (HELIX) cohort: a European population-based exposome cohort—cohort profile [PDF]

open access: yesBMJ Open
Purpose The Human Early Life Exposome (HELIX) cohort was established to assess a wide range of environmental exposures (the exposome) during early life and study the effects of the early life exposome on child and adolescent health outcomes and molecular
Martine Vrijheid   +33 more
doaj   +2 more sources

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