Results 11 to 20 of about 9,490 (157)

The exposome and the future of epidemiology: a vision and prospect [PDF]

Environmental Health and Toxicology, 2017
It is widely accepted that a relatively small proportion of chronic disease can be explained by genetic factors alone. Although information about environmental exposure is important to comprehensively evaluate chronic diseases, this information is not ...
Kyoung-Nam Kim, Yun-Chul Hong
doaj   +1 more source

An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction

Scientific Reports, 2021
Complementary to the genome, the concept of exposome has been proposed to capture the totality of human environmental exposures. While there has been some recent progress on the construction of the exposome, few tools exist that can integrate the genome ...
Xuan Zhou, S. Hong Lee
doaj   +1 more source

Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures

Environment International, 2021
Challenges in the assessment of the health effects of the exposome, defined as encompassing all environmental exposures from the prenatal period onwards, include a possibly high rate of false positive signals.
Solène Cadiou, Xavier Basagaña, Juan R. Gonzalez, Johanna Lepeule, Martine Vrijheid, Valérie Siroux, Rémy Slama   +6 more
doaj   +1 more source

The Educational Exposome: A life-course socioenvironmental framework for advancing Alzheimer's disease and ADRD research. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The exposome encompasses all environmental exposures across the life course, yet educational environments, a critical socioenvironmental exposure, remain underexplored despite their role in cognitive aging and Alzheimer's disease and related dementias (AD/ADRD).
Johnson KE.
europepmc   +2 more sources

Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research

Environment International, 2023
Outcome-wide analysis can offer several benefits, including increased power to detect weak signals and the ability to identify exposures with multiple effects on health, which may be good targets for preventive measures.
Augusto Anguita-Ruiz, Ines Amine, Nikos Stratakis, Lea Maitre, Jordi Julvez, Jose Urquiza, Chongliang Luo, Mark Nieuwenhuijsen, Cathrine Thomsen, Regina Grazuleviciene, Barbara Heude, Rosemary McEachan, Marina Vafeiadi, Leda Chatzi, John Wright, Tiffany C. Yang, Rémy Slama, Valérie Siroux, Martine Vrijheid, Xavier Basagaña   +19 more
doaj   +1 more source

Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis

Environment International, 2021
Background: Polychlorinated biphenyls (PCBs) are a large family of man-made organic, ubiquitous, and persistent contaminants with endocrine-disrupting properties.
Thibault Fiolet, Yahya Mahamat-Saleh, Pauline Frenoy, Marina Kvaskoff, Francesca Romana Mancini   +4 more
doaj   +1 more source

Application of two statistical approaches (Bayesian Kernel Machine Regression and Principal Component Regression) to assess breast cancer risk in association to exposure to mixtures of brominated flame retardants and per- and polyfluorinated alkylated substances in the E3N cohort

Environmental Health, 2022
Background Brominated flame retardants (BFR) and per- and polyfluorinated alkylated substances (PFAS) are two groups of substances suspected to act as endocrine disruptors. Such substances could therefore be implicated in the occurrence of breast cancer,
Pauline Frenoy, Vittorio Perduca, German Cano-Sancho, Jean-Philippe Antignac, Gianluca Severi, Francesca Romana Mancini   +5 more
doaj   +1 more source

Exposome approach for identifying modifiable factors for the prevention of colorectal cancer

Scientific Reports, 2022
Previous studies have shown certain exposure factors (such as lifestyle and metabolism) are associated with colorectal cancer (CRC) events. However, the application of the exposome theoretical frame and the extent to which the exposome domain can ...
Nanqian Chen, Hailun Liang, Tao Huang, Ninghao Huang   +3 more
doaj   +1 more source

Merging the exposome into an integrated framework for “omics” sciences

iScience, 2022
Summary: The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual’s health over their life course.
Elliott J. Price, Chiara M. Vitale, Gary W. Miller, Arthur David, Robert Barouki, Karine Audouze, Douglas I. Walker, Jean-Philippe Antignac, Xavier Coumoul, Vincent Bessonneau, Jana Klánová   +10 more
doaj   +1 more source

Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming

Communications Biology, 2023
The integrated stress response (ISR) plays a pivotal role in the cellular stress response, primarily through global translational arrest and the upregulation of cellular adaptation-linked molecules.
Navin Ray, Seung Jun Park, Hoyung Jung, Juil Kim, Tamas Korcsmaros, Yuseok Moon   +5 more
doaj   +1 more source