Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Performance Profiles of Short DNA Barcode Segments for Family Level Detection of Asteraceae Within Asterales. [PDF]
Jiang S +10 more
europepmc +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Rethinking Preoperative MRSA/MSSA Screening Through Molecular Triage. [PDF]
Carpenter RE, Whitlock G.
europepmc +1 more source
Beyond the Score: Fixed-Budget Benchmarking of Virtual Screening Integration Strategies for Decision-Centric Drug Discovery. [PDF]
Tomarchio EG, Buccheri R, Rescifina A.
europepmc +1 more source
Special Issue "Antiviral Drugs Discovery". [PDF]
Tao S, Zhou Z, Liu X, Kang D.
europepmc +1 more source
Defining Functional T Cell Receptor Repertoires With Nanovial-Based Screening. [PDF]
Di Carlo D.
europepmc +1 more source
Measuring performance in cancer services during COVID-19 and beyond: a novel case throughput metric using NHS Cancer Waiting Times data. [PDF]
Lam CHM, Mason T, Hollingsworth B.
europepmc +1 more source
Implementation and performance of a national pilot programme for eliminating mother-to-child transmission of syphilis: a retrospective cross-sectional study in China. [PDF]
Luo Y +6 more
europepmc +1 more source
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Non-targeted Screening in Environmental Monitoring Programs
2019Contaminant monitoring programs have been tasked with understanding the fate and transport of toxic chemicals in the environment. Mass spectrometry based methods have traditionally been developed to maximize sensitivity and accuracy of a select set of target compounds. As mass spectrometry methods have advanced, so has the breadth of questions proposed
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