Results 61 to 70 of about 14,318,687 (253)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Newly identified SpoVAF/FigP complex: the role in Bacillus subtilis spore germination at moderate high pressure and influencing factors

Applied and Environmental Microbiology
The SpoVAF/FigP complex, a newly identified dormant spore ion channel, has been shown to amplify the response of germinant receptors (GRs) to nutrient germinants. However, its contribution to high-pressure-induced germination remains unexplored.
Fengzhi Lyu, Ziqi Gong, Tianyu Zhang, Dong Yang, Lei Rao, Xiaojun Liao   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

New insights into the structure-based mechanism of Bacillus subtilis spore resistance to high hydrostatic pressure

Applied and Environmental Microbiology
The exceptional pressure resistance of bacterial spores limits the application of high hydrostatic pressure (HHP) in food sterilization, yet the underlying mechanisms remain poorly understood. Here, we examined how structural modifications (coat, cortex,
Shengnan Kang, Ziqi Gong, Junyi Zhang, Qiuyu Meng, Jinyang Li, Fengzhi Lyu, Lei Rao, Xiaojun Liao   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Research Progress on Fermentation Microorganisms and Flavor Compounds in Pixian Broad Bean Paste

Shipin gongye ke-ji
Pixian broad bean paste (PBBP), a quintessential condiment of Sichuan cuisine, is widely cherished by consumers for its unique sweet and spicy taste, as well as its vibrant color.
Wen YANG, Jiayue XU, Peishu YANG, Yungui LAN, Sijia PENG, Yang ZHAO, Binyuan ZHAO, Dong YANG, Liang ZHAO, Xiaojun LIAO   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

THERMAL AND ADVANCED NON-THERMAL FOOD PROCESSING METHODS

Thermal and advanced non-thermal processing technologies are central to ensuring food safety, extending shelf life, and maintaining product quality in modern food systems.
Karthik Medabalimi, Martha Verghese
core   +1 more source

Optimizing germination conditions for Alicyclobacillus acidoterrestris spores, and achieving efficient inactivation via high hydrostatic pressure using a germination-inactivation strategy

Food Innovation and Advances
The 'germination-inactivation' strategy can potentially eliminate Alicyclobacillus acidoterrestris spores by exploiting the loss of their resistance that occurs during germination. However, the germination behavior of A.
Yumeng Ding, Fengzhi Lyu, Ziqi Gong, Dong Yang, Yongtao Wang, Lei Rao   +5 more
doaj   +1 more source