Results 61 to 70 of about 233,549 (265)

Stability criteria, atomization and non-thermal processes in liquids

Ultrasonics Sonochemistry, 2008
Analyzing the first equation in the BBGKY chain of equations for an equilibrium liquid-gas system, we derived the analytical expression for the atom work function from liquid into gas. The coupling between the atom work function from liquid into vacuum and the stability criterion of liquid in limiting points of the first type was shown (using I.Z ...
Kaim, Y. S., Kaim, S. D.
openaire   +3 more sources

New insights into the structure-based mechanism of Bacillus subtilis spore resistance to high hydrostatic pressure

Applied and Environmental Microbiology
The exceptional pressure resistance of bacterial spores limits the application of high hydrostatic pressure (HHP) in food sterilization, yet the underlying mechanisms remain poorly understood. Here, we examined how structural modifications (coat, cortex,
Shengnan Kang, Ziqi Gong, Junyi Zhang, Qiuyu Meng, Jinyang Li, Fengzhi Lyu, Lei Rao, Xiaojun Liao   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optimization of Non-Thermal Technology in Food Processing

Foods
Any new food processing technology must first be subjected to extensive research to verify the safety and quality of the food that it creates [...]
Milan Houška, Roman Buckow
openaire   +3 more sources

Optimizing germination conditions for Alicyclobacillus acidoterrestris spores, and achieving efficient inactivation via high hydrostatic pressure using a germination-inactivation strategy

Food Innovation and Advances
The 'germination-inactivation' strategy can potentially eliminate Alicyclobacillus acidoterrestris spores by exploiting the loss of their resistance that occurs during germination. However, the germination behavior of A.
Yumeng Ding, Fengzhi Lyu, Ziqi Gong, Dong Yang, Yongtao Wang, Lei Rao   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Advances in the Effects of High-pressure Processing on Milk Quality: From Microbial Safety to Nutritional Enhancement

Shipin gongye ke-ji
As an advanced non-thermal food-processing technology, high-pressure processing (HPP) is characterized by low processing temperatures and minimal nutritional loss, demonstrating unique advantages in maintaining food quality.
Qiuyu MENG, Fengzhi LÜ, Dong YANG, Yongtao WANG, Liang ZHAO, Ning GUAN, Xiaojun ZHANG, Gang FENG, Lei RAO, Xiaojun LIAO   +9 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source