Results 71 to 80 of about 14,318,687 (253)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Advances in the Effects of High-pressure Processing on Milk Quality: From Microbial Safety to Nutritional Enhancement

Shipin gongye ke-ji
As an advanced non-thermal food-processing technology, high-pressure processing (HPP) is characterized by low processing temperatures and minimal nutritional loss, demonstrating unique advantages in maintaining food quality.
Qiuyu MENG, Fengzhi LÜ, Dong YANG, Yongtao WANG, Liang ZHAO, Ning GUAN, Xiaojun ZHANG, Gang FENG, Lei RAO, Xiaojun LIAO   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chemometric Evaluation of Pulping Suitability of Four Kinds of Horn Peppers from Inner Mongolia

Shipin gongye ke-ji
Chili pulp represents a new category of chili-based products, functioning as the fundamental base material for downstream applications including chili sauces, hot pot soup bases, and compound seasonings.
Yufei TIAN, Geqing LI, Jiaxin SUN, Qiwei ZHOU, Yan MA, Liang ZHAO, Xiaojun LIAO   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Non-thermal food processing : impact on chemical, nutritional and bioactive components

, 2011
Non-thermal food processing : impact on chemical, nutritional and bioactive ...
L Wakeling (9865292), Shirani Gamlath (13093986)   +1 more
core  

Detecção e caracterização de defeitos internos por termografia infravermelha pulsada [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2014.A termografia pulsada (TP) é uma técnica promissora para a avaliação não-destrutiva de materiais.
Rodríguez, Fernando de Jésus López
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Visualization and modelling of the thermal inactivation of bacteria in a model food [PDF]

, 1999
A large number of incidents of food poisoning have been linked to undercooked meat products. The use of mathematical modelling to describe heat transfer within foods, combined with data describing bacterial thermal inactivation, may prove useful in ...
Hocking, Paul M, Bellara, Sanjay R, Fryer, Peter J., McFarlane, Caroline M, Thomas, Colin R, Mackey, Bernard M   +5 more
core  

The Application of ANN and ANFIS Prediction Models for Thermal Error Compensation on CNC Machine Tools [PDF]

Thermal errors can have significant effects on Computer Numerical Control (CNC) machine tool accuracy. The errors come from thermal deformations of the machine elements caused by heat sources within the machine structure or from ambient temperature ...
Abdulshahed, Ali
core   +3 more sources