Results 61 to 70 of about 17,865,208 (292)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Energies, 2020 This paper describes a correlation of partial discharge phase-resolved patterns with an optical imaging performed in a non-uniform electric field configuration.
Marek Florkowski +3 more
doaj +1 more source
The demagnetizing field of a non-uniform rectangular prism [PDF]
, 2010 The effect of demagnetization on the magnetic properties of a rectangular ferromagnetic prism under non-uniform conditions is investigated. A numerical model for solving the spatially varying internal magnetic field is developed, validated and applied to
Bjørk, Rasmus +11 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Visual Perception in Non-uniform Fields
Journal of Light & Visual Environment, 1992 Adaptation for uniform fields and for non-uniform fields is compared. Experimentally, the luminance difference thresholds for the Foveal Adaptation Luminance (Lf), the Background Luminance (Lb) and the Equivalent Veiling Luminance (Leq) are separately investigated.
openaire +2 more sources
Non-uniform electric field-induced yeast cell electrokinetic behavior
Ingeniería e Investigación, 2008 Common dielectrophoresis (c-DEP, i.e. neutral matter motion induced by non-uniform electric fields) has become a basic pheno-menon of biochips intended for medical, biological and chemical assays, especially when they imply bioparticle handling.
Flavio Humberto Fernández Morales +2 more
doaj
Magnetic field induced orientational transitions in liquid crystals doped with carbon nanotubes
Beilstein Journal of Nanotechnology, 2017 We propose a continuum theory of orientational phase transitions induced by an external magnetic field in a suspension of carbon nanotubes in a nematic liquid crystal.
Danil A. Petrov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source