Results 1 to 10 of about 397,349 (168)
Improved osteogenic vector for non-viral gene therapy [PDF]
European Cells & Materials, 2016 Therapeutic compensation of deficient bone regeneration is a challenging task and a topic of on-going search for novel treatment strategies. One promising approach for improvement involves non-viral gene delivery using the bone morphogenetic protein-2 ...
ARA Hacobian +7 more
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An Electrostatically Self-Assembled Ternary Nanocomplex as a Non-Viral Vector for the Delivery of Plasmid DNA into Human Adipose-Derived Stem Cells [PDF]
Molecules, 2016 In this study, we developed electrostatically self-assembled ternary nanocomplexes as a safe and effective non-viral vector for the delivery of plasmid DNA (pDNA) into human adipose-derived stem cells (hASCs).
Sun-Hee Cho +3 more
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CRISPR/Cas9 systems: Delivery technologies and biomedical applications
Asian Journal of Pharmaceutical Sciences, 2023 The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a significant revolution in the realm of managing human diseases, establishing animal ...
Yimin Du +4 more
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Advances of non-viral nanometer vectors delivery systemfor siRNA
生物医学转化, 2021 The delivery of small interfering RNA is now mainly through viral vector delivery, chemicalmodification delivery, microinjection delivery, and non-viral nanometer vector delivery.
Geng Xiang, Huang Meizhou, Li Jianyong
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Neurotransfection activity of gene preparations: introduction to dressing formulations [PDF]
Farmacja Polska, 2021 Background Preparations for local anticancer therapy based on a biodegradable, dressing matrices are included in the treatment regimens of malignant gliomas of the brain.
Żaneta Słyk +4 more
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Non-viral vectors for RNA delivery
Journal of Controlled Release, 2022 RNA-based therapy is a promising and potential strategy for disease treatment by introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides (ASO) to modulate gene expression in specific cells. It is exciting that mRNA encoding the spike protein of COVID-19 (coronavirus
Yan, Yi +5 more
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Cell Reports: Methods, 2023 Summary: The flip-excision switch (FLEX) system with an adeno-associated viral (AAV) vector allows expression of transgenes in specific cell populations having Cre recombinase. A significant issue with this system is non-specific expression of transgenes
Natsuki Matsushita +7 more
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Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant
Moosa Rahimi Ghiasi +10 more
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COVID-19 Vaccines over Three Years after the Outbreak of the COVID-19 Epidemic
Viruses, 2023 The outbreak of COVID-19 started in December 2019 and spread rapidly all over the world. It became clear that the development of an effective vaccine was the only way to stop the pandemic.
Aleksandra Anna Zasada +8 more
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Non‐viral vectors for cancer therapy [PDF]
Cancer Science, 2006 Cancers are diverse and often resistant to therapeutic strategies. Gene therapy has yet to meet the promise of a breakthrough in cancer therapy. There are several barriers to overcome in cancer gene therapy. One of the biggest challenges is the design of appropriate vectors. Numerous viral and non‐viral methods for gene transfer have been developed for
Kaneda, Y, Tabata, Y
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