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Advances in Non-Viral DNA Vectors for Gene Therapy [PDF]
Genes, 2017 Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy delivery in the clinic. Viral vectors, however, have certain issues involving genome integration, the inability to be delivered repeatedly, and possible host rejection. Fortunately, development of non-viral DNA vectors has progressed steadily, especially in plasmid
Hardee, Cinnamon L. +3 more
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Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies
Nanomaterials, 2019 Glioblastoma multiforme is the most common and aggressive primary brain tumor. Even with aggressive treatment including surgical resection, radiation, and chemotherapy, patient outcomes remain poor, with five-year survival rates at only 10%.
Breanne Caffery +2 more
doaj +1 more source
Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Biomedicines, 2013 Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso +2 more
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Recent Advances in Molecular Biology of Human Bocavirus 1 and Its Applications
Frontiers in Microbiology, 2021 Human bocavirus 1 (HBoV1) was discovered in human nasopharyngeal specimens in 2005. It is an autonomous human parvovirus and causes acute respiratory tract infections in young children.
Liting Shao +3 more
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Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]
, 2009 Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia +23 more
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Exploring nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders
Türk Biyokimya Dergisi, 2023 MicroRNAs (miRNAs) are small non-coding molecules that play a pivotal part in brain development and the processes of establishment and maintenance of dendrites and neurite outgrowth by modulating gene expression.
Mushtaq Gohar +6 more
doaj +1 more source
Flavivirus Persistence in Wildlife Populations
Viruses, 2021 A substantial number of humans are at risk for infection by vector-borne flaviviruses, resulting in considerable morbidity and mortality worldwide. These viruses also infect wildlife at a considerable rate, persistently cycling between ticks/mosquitoes ...
Maria Raisa Blahove +1 more
doaj +1 more source
Non-viral approaches to gene therapy [PDF]
, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Wagner, Ernst, Cotten, Matt
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Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives
, 2021 Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, for which no effective treatment is yet available to either slow or terminate it.
Gayathri R Ediriweera (20256288) +4 more
core +1 more source
Gene Therapy for Regenerative Medicine
Pharmaceutics, 2023 The development of biological methods over the past decade has stimulated great interest in the possibility to regenerate human tissues. Advances in stem cell research, gene therapy, and tissue engineering have accelerated the technology in tissue and ...
Hossein Hosseinkhani +3 more
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