Results 11 to 20 of about 11,612,374 (304)
An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma
International Journal of Nanomedicine, 2012 Min Shen,1,* Faming Gong,3,* Pengfei Pang,1,* Kangshun Zhu,1 Xiaochun Meng,1 Chun Wu,1 Jin Wang,1 Hong Shan,1,2 Xintao Shuai3,41Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China ...
Shen M +8 more
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Novel gene therapy viral vector using non-oncogenic lymphotropic herpesvirus. [PDF]
PLoS ONE, 2013 Despite the use of retroviral vectors, efficiently introducing target genes into immunocytes such as T cells is difficult. In addition, retroviral vectors carry risks associated with the oncogenicity of the native virus and the potential for introducing ...
Akihiro Shimizu +6 more
doaj +1 more source
Emerging non-viral vectors for gene delivery
Journal of Nanobiotechnology, 2023 AbstractGene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit manipulation of gene expression. However, the clinical implementation of gene therapy remains substantially impeded by the lack of safe and efficient gene ...
Chenfei Wang +8 more
openaire +3 more sources
Tropical Medicine and Infectious Disease, 2023 The Thai government implemented COVID-19 booster vaccines to prevent morbidity and mortality during the spreading of the Omicron variant. However, little is known about which types of vaccine should be invested in as the booster dose for the Thai ...
Kanchanok Sirison +4 more
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Peptide-Based Vectors for Gene Delivery
Chemistry, 2023 Gene therapy is the ultimate therapeutic technology for diseases related to gene abnormality. However, the use of DNA alone has serious problems, such as poor stability and difficulty in entering target cells. The development of a safe and efficient gene
Juan Yang, Guo-Feng Luo
doaj +1 more source
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco +7 more
core +1 more source
Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]
, 2009 The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt +6 more
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Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]
, 2012 BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly +8 more
core +1 more source
Characterizing piggyBat—a transposase for genetic modification of T cells
Molecular Therapy: Methods & Clinical Development, 2022 Chimeric antigen receptor (CAR) T cells targeting CD19 have demonstrated remarkable efficacy in the treatment of B cell malignancies. Current CAR T cell manufacturing protocols are complex and costly due to their reliance on viral vectors.
Gaurav Sutrave +7 more
doaj +1 more source
Journal of Orofacial Sciences, 2013 Gene therapy "the use of genes as medicine" involves the transfer of a therapeutic or working copy of a gene into specific cells of an individual in order to repair a faulty gene copy. The technique may be used to replace a faulty gene, or to introduce a
Sudip Indu +3 more
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