Results 61 to 70 of about 11,612,374 (304)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
TERAPI GEN: DARI BIOTEKNOLOGI UNTUK KESEHATAN
Al-Kauniyah Jurnal Biologi, 2017 Abstrak Rekayasa genetika dilakukannya untuk manipulasi gen-gen tertentu sehingga ekspresi gen dapat dikontrol dan produknya dapat dimanfaatkan untuk tujuan tertentu, salah satunya untuk pengobatan penyakit dengan terapi gen.
Dyah Ayu Widyastuti
doaj +1 more source
An optimised method for the production of MERS-CoV spike expressing viral pseudotypes [PDF]
, 2015 The production and use of pseudotyped viral particles is widely established for many viruses, and applications in the fields of serology and vaccine development are manifold.
Ferrara, Francesca +5 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Revista Argentina de Microbiología, 2007 El virus vaccinia Ankara modificado (MVA) constituye un buen candidato para el desarrollo de vectores virales de expresión no replicativos porque no replica en la mayoría de las células de mamíferos. Para la producción de MVA recombinantes es fundamental
M. F. Ferrer +2 more
doaj
The Development of Functional Non-Viral Vectors for Gene Delivery [PDF]
International Journal of Molecular Sciences, 2019 Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases. This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or RNA, into the cell. Because of their negative charge and considerable larger size, the delivery of these molecules, in general, should be mediated by gene vectors.
Suryaji Patil +9 more
openaire +2 more sources
Non-viral strategies for ocular gene delivery
, 2017 The success of gene therapy relies on efficient gene transfer and stable transgene expression. The in vivo efficiency is determined by the delivery vector, route of administration, therapeutic gene, and target cells. While some requirements are common to
Rosa Da Costa, Ana +5 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Cationic Liposomes Modified with Polyallylamine as a Gene Carrier: Preparation, Characterization and Transfection Efficiency Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: Cationic polymers and cationic liposomes have shown to be effective non-viral gene delivery vectors. In this study, we tried to improve the transfection efficiency by employing the advantages of both.
Reza Kazemi Oskuee +4 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Shivaranjani Shivalingaiah +4 more
core +1 more source