Results 91 to 100 of about 122,669 (246)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis

Pharmacological Reports, 2020
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Globally, it is currently the most common liver disease and is estimated to affect up to 25% of the population.
Natalia Pydyn, K. Miękus, J. Jura, J. Kotlinowski   +3 more
semanticscholar   +1 more source

Fat‐Corrected Non‐Gaussian Diffusion MRI for Liver Fibrosis Assessment in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background In patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), non‐Gaussian diffusion—weighted imaging (DWI) has been proposed for the diagnosis of liver fibrosis, but its measurement is partially confounded by steatosis.
Omaïma Saïd, Sabrina Doblas, Valérie Paradis, Pierre Bedossa, Dominique Valla, Cédric Laouénan, Laurent Castera, Bernard E. Van Beers, Philippe Garteiser   +8 more
wiley   +1 more source

A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Hepatology, 2018
The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of CC chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis (LF).
S. Friedman, V. Ratziu, S. Harrison, M. Abdelmalek, G. Aithal, J. Caballería, S. Francque, G. Farrell, K. Kowdley, A. Craxì, K. Simon, L. Fischer, Liza Melchor-Khan, Jeffrey D. Vest, B. Wiens, P. Vig, S. Seyedkazemi, Z. Goodman, V. Wong, R. Loomba, F. Tacke, A. Sanyal, E. Lefebvre   +22 more
semanticscholar   +1 more source

Evaluation of Hepatic Steatosis and Fibrosis in Steatotic Liver Disease Ultrasound‐Derived Fat Fraction (UDFF) and Auto pSWE by Using Deep Abdominal Transducer (DAX) and Liver Biopsy Correlation

Journal of Ultrasound in Medicine, EarlyView.
Objectives To evaluate the diagnostic performance of ultrasound‐derived fat fraction (UDFF) in detecting and grading hepatosteatosis using liver histology as the reference, and to assess the effectiveness of point shear wave elastography (pSWE), UDFF, and auto‐pSWE in diagnosing steatohepatitis and detecting fibrosis in metabolic dysfunction‐associated
Ahmet Burak Kale, Mustafa Faraşat, Gökhan Pekindil, Semin Ayhan, Serdar Tarhan, Tahir Buran   +5 more
wiley   +1 more source

Hepatic connexin 32 associates with nonalcoholic fatty liver disease severity

Hepatology Communications, 2018
Emerging data highlight the critical role for the innate immune system in the progression of nonalcoholic fatty liver disease (NAFLD). Connexin 32 (Cx32), the primary liver gap junction protein, is capable of modulating hepatic innate immune responses ...
Jay Luther, Manish K. Gala, Nynke Borren, Ricard Masia, Russell P. Goodman, Ida Hatoum Moeller, Erik DiGiacomo, Alyssa Ehrlich, Andrew Warren, Martin L. Yarmush, Ashwin Ananthakrishnan, Kathleen Corey, Lee M. Kaplan, Sangeeta Bhatia, Raymond T. Chung, Suraj J. Patel   +15 more
doaj   +1 more source

Osteoprotegerin deficiency aggravates methionine- choline- deficient diet-induced nonalcoholic steatohepatitis in mice [PDF]

, 2022
Shaobo Wu, Yao Wu, Lan Lin, Changshun Ruan, Fang Li, Rong Chen, Hongxin Du, Xianxiang Zhang, Xiaohe Luo   +8 more
openalex   +1 more source

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine MASH Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction‐associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non‐invasive biomarkers for tracking disease progression.
Szu‐Jen Wang, Yung‐Ho Wang, Jee‐Fu Huang, En‐Sheng Lin, Wei‐Shiun Chen, Chia‐Yang Li, Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu, Shu‐Chi Wang   +9 more
wiley   +1 more source

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

Hepatology Communications, 2020
The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by ...
Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt   +17 more
doaj   +1 more source

Technical acoustic measurements combined with clinical parameters for differential diagnosis of nonalcoholic steatohepatitis [PDF]

, 2023
Yanan Zhao, Chen Qiu, Yiping Dong, Xuchu Wang, Jifan Chen, Jianting Yao, Yifan Jiang, Chao Zhang, Huifang Weng, Yajing Liu, Yik Ning Wong, Pintong Huang   +11 more
openalex   +1 more source