Results 71 to 80 of about 2,835,571 (143)

Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]

, 1999
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Puhl, G., Neuhaus, P., Schön, M. R., Hammer, C., Matthes, M., Heil, W., Lemmens, H.-P., Padval, D.   +7 more
core   +1 more source

Metabolomic Profiling of Fatty Acid and Amino AcidMetabolism in Youth With Obesity and Type 2 Diabetes [PDF]

, 2012
OBJECTIVE We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents.
Bacha, Fida, Michaliszyn, Sara F., Mihalik, Stephanie J., Chace, Donald H., Arslanian, Silva A., Lee, SoJung, De las Heras Montero, Javier Adolfo, DeJesus, Victor R., Vockley, Jerry   +8 more
core   +1 more source

Protocol for click labeling of HIV-1 envelope on amber-free virions prepared using genetic code expansion

STAR Protocols
Summary: Site-specific fluorescent labeling of HIV-1 proteins enables direct visualization of their dynamics and trafficking. Here, we present a protocol to label HIV-1 envelope (Env) glycoproteins on virions using genetic code expansion and click ...
Wang Xu, Narendra Kumar Gonepudi, Maolin Lu   +2 more
doaj   +1 more source

Fabrication of hydroxyapatite sponges by dextran sulphate/amino acid templating [PDF]

, 2005
We report a new template-directed method for the fabrication of hydroxyapatite (HAp) sponges by using amino-acid-coated HAp nanoparticles dispersed within a viscous polysaccharide (dextran sulfate) matrix, and describe the use of these materials for the ...
Walsh, Dominic, Gonzalez-McQuire, Rosanna, Oreffo, ROC, Gonzalez-Mcquire, R, Walsh, D, Chane-Ching, Jean-Yves, Green, David, Chane-Ching, JY, Mann, S, Oreffo, Richard O.C., Hall, SR, Mann, Stephen, Green, D, Hall, Simon   +13 more
core   +1 more source

Expanding the genetic code: phage-driven evolution of pyrrolysyl-synthetase for site-specific incorporation of synthetic phenylalanine and tyrosine derivatives

Frontiers in Molecular Biosciences
IntroductionPyrrolysyl-tRNA synthetase (PylRS) is a key enzyme for the site-specific incorporation of non-canonical amino acids (ncAAs) into proteins. However, its native form has a limited substrate scope.
Anastasia Dakhnevich, Sabina Miasoutova, Danila Iliushin, Aleksey Rozanov, Roman Ivanov   +4 more
doaj   +1 more source

Cryo-EM structure of the LARS1:IARS1 complex reveals a nutrient-responsive switch controlling mTORC1 signaling

Nature Communications
Aminoacyl-tRNA synthetases (ARSs) assemble into the multi-tRNA synthetase complex (MSC) to mediate noncanonical functions in cell signaling and stress responses. Among them, human cytosolic leucyl-tRNA synthetase 1 (LARS1) plays a central role in sensing
Youjin Kim, Joo-Chan Kim, Do-Wook Kim, Jinwoo Kim, Jaehun Choi, Seo Young Park, Jimin Lee, Ina Yoon, Sunghoon Kim, Jin Young Kang, Hee-Sung Park   +10 more
doaj   +1 more source

Developments in plant breeding for improved nutritional quality of soya beans I. Protein and amino acid content [PDF]

, 2000
Soya beans, like other legumes, contain low concentrations of the nutritionally essential sulphur amino acid, methionine. Cysteine, although not an essential amino acid because it can be synthesized from methionine, also influences the nutritional ...
Clarke, E, Wiseman, J
core  

A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation

Cell Reports
Summary: Neuronal response to changes in nutrient availability is critical for maintaining metabolic homeostasis and organismal survival. Nevertheless, we know little about the molecular players that regulate and maintain neurotransmission under ...
Megumi Mori, Grant Kauwe, Ammar Aly, Edward H. Liao, Gary Scott, A. Pejmun Haghighi   +5 more
doaj   +1 more source

Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Stem Cell Research & Therapy
Background Human induced pluripotent stem cells (hiPSCs) and their differentiated cell types have a great potential for tissue repair and regeneration. While the primary focus of using hiPSCs has historically been to regenerate damaged tissue, emerging ...
Divya Sridharan, Julie A. Dougherty, Uzair Ahmed, Shridhar K. Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E. Knoblaugh, Harpreet Singh, Elizabeth D. Kirby, Mahmood Khan   +10 more
doaj   +1 more source

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy

eLife
We report a minimally disruptive labeling strategy for stress granule protein, G3BP Stress Granule Assembly Factor 1 (G3BP1), and ALS-linked protein, TAR DNA-binding protein 43 (TDP-43), using the fluorescent non-canonical amino acid Anap. By integrating
Hao Chen, Haocheng Wang, Yu-Ning Lu, Peng Chen, Zhongfan Zheng, Tao Zhang, Jiou Wang   +6 more
doaj   +1 more source