Results 51 to 60 of about 2,835,571 (143)

The invertebrate transporters of SLC6 family are able to transport D-amino acid

, 2017
Neutral amino acids, which predominantly represent essential substrates in animals, are absorbed via a B0 transport system (the Broad neutral amino acid system).
E. Bossi, M. Castagna, A. Vollero, R. Cinquetti   +3 more
core   +2 more sources

Peptides encoded by short ORFs control development and define a new eukaryotic gene family.

PLoS Biology, 2007
Despite recent advances in developmental biology, and the sequencing and annotation of genomes, key questions regarding the organisation of cells into embryos remain.
Máximo Ibo Galindo, José Ignacio Pueyo, Sylvaine Fouix, Sarah Anne Bishop, Juan Pablo Couso   +4 more
doaj   +1 more source

Fluorescent non-canonical amino acid provides insight into the human serotonin transporter

Nature Communications
The serotonin transporter (SERT), responsible for the reuptake of released serotonin, serves as a major target for antidepressants and psychostimulants. Nevertheless, refining the mechanistic models for SERT remains challenging.
Andreas Nygaard, Linda G. Zachariassen, Kathrine S. Larsen, Anders S. Kristensen, Claus J. Loland   +4 more
doaj   +1 more source

Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues

Genes and Environment, 2023
Background Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs. Consideration The requirements for assessing the genotoxicity of pharmaceuticals differ
Masayuki Mishima, Kei-ichi Sugiyama
doaj   +1 more source

Ribosome engineering enhances genetic code expansion in Saccharomyces cerevisiae

Synthetic and Systems Biotechnology
Genetic code expansion enables the site-specific installation of noncanonical amino acids (ncAAs) into proteins, but its limited efficiency in eukaryotes remains a major barrier to broader application.
Xiaoxu Chen, Wenlu Shen, Xianqing Chen, Fangfang Zhang, Bo Yang, Zhiyong Yue, Guanghou Zhao   +6 more
doaj   +1 more source

Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture [PDF]

, 2014
An approach to proteomic analysis that combines bioorthogonal noncanonical amino acid tagging (BONCAT) and pulsed stable isotope labeling with amino acids in cell culture (pSILAC) provides accurate quantitative information about rates of cellular protein
Sweredoski, Michael J., Xie, Y., Schuman, E., Schuman, Erin M., Tirrell, David A., Sweredoski, M., Qi, Y., Xie, Yushu J., Qi, Yutao, Hess, Sonja, Bagert, J., Hess, S., Tirrell, D., Bagert, John D.   +13 more
core   +1 more source

General synthesis of conformationally constrained noncanonical amino acids with C(sp3)-rich benzene bioisosteres [PDF]

Recent years have seen novel modalities emerge for the treatment of human diseases resulting in an increase in beyond rule of 5 (bRo5) chemical matter. As a result, synthetic innovations aiming at enabling rapid access of complex bRo5 molecular entities
Justin, Newman, David, Smith, Xiao, Wang, Lei, Yue, Adam, Beard, Xiaoshen, Ma, Miroslawa, Darlak, Lisa, Nogel, Samantha, Burgess, Mark, Pietrafitta   +9 more
core   +1 more source

Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid

Nature Communications
The creation of designer enzymes by incorporating genetically encoded non-canonical amino acids (ncAAs) could significantly expand the catalytic repertoire of the enzyme universe for abiological transformations.
Wei Huang, Shiping Wang, Ya Wei, Yuting Bai, Zhixi Zhu, Dejing Yin, Tao Liu, Xiang Sheng, Zhi Zhou   +8 more
doaj   +1 more source

Development of orthogonal aminoacyl-tRNA synthetase mutant for incorporating a non-canonical amino acid

AMB Express
Genetic code expansion involves introducing non-canonical amino acids (ncAAs) with unique functional groups into proteins to broaden their applications.
Dongheon Lee, Ja Gyung Kim, Tae Wan Kim, Jong-il Choi   +3 more
doaj   +1 more source

PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif [PDF]

, 2011
PAPD5 is one of the seven members of the family of noncanonical poly(A) polymerases in human cells. PAPD5 was shown to polyadenylate aberrant pre-ribosomal RNAs in vivo, similar to degradation-mediating polyadenylation by the noncanonical poly(A ...
Bilen, B., Keller, W., Mihaela Zavolan, Biter Bilen, Zavolan, M., Walter Keller, Rammelt, C., Christiane Rammelt   +7 more
core   +1 more source