Results 91 to 100 of about 49,716 (243)

Impact of a low‐carbohydrate diet on cardiometabolic parameters in individuals with and without diabetes: An 8‐year longitudinal study within the ELSA‐Brasil cohort

Nutrition in Clinical Practice, EarlyView.
Abstract Background Low‐carbohydrate diets (LCDs) are widely adopted for metabolic management, but their long‐term cardiometabolic effects in diverse populations remain unclear. We aimed to evaluate the association between self‐selected moderate LCD adherence and cardiometabolic parameters in individuals with and without diabetes.
Leticia Batista de Azevedo, Haysla Xavier Martins, Oscar Geovanny Enriquez‐Martinez, Maria del Carmen Bisi Molina   +3 more
wiley   +1 more source

Interventions for the Diagnosis and Management of Otosclerosis: An Umbrella Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Perform an umbrella review (a systematic review of systematic reviews) to identify interventions for the prevention, diagnosis, and management of otosclerosis, to inform the development of the World Health Organization (WHO) Package of Ear and Hearing Care Interventions (PEHCI). Data Sources PubMed, Scopus, and Ovid MEDLINE databases
Isabelle J. Chau, Lauren R. McCray, Shaun A. Nguyen, Robert F. Labadie, Carolina Der, Lauren K. Dillard   +5 more
wiley   +1 more source

Analysis of trends in cancer mortality and the years of life lost in six provinces in northwest China from 2013 to 2021

Scientific Reports
Cancer is a major cause of death and morbidity in China. We aimed to analyze the trends in cancer mortality in six provinces in northwest China (Xinjiang Uyghur Autonomous Region, Qinghai Province, Shaanxi Province, Gansu Province, Ningxia Hui Autonomous
Haitao Bi, Ning Wang, Xiaolin Yu, Yunning Liu, Baohua Wang   +4 more
doaj   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

National and subnational burden and causes of anemia in China from 1990 to 2023: findings from the Global Burden of Disease Study 2023

Military Medical Research
Background Anemia is a major global health problem. There were 89% of all anemia-related disabilities in developing countries. We aim to analyze the burden of anemia and its underlying causes in China from 1990 to 2023.
Zheng Long, Ling-Ling Yu, Fan-Shu Yan, Pei-Pei Li, Li-Jun Wang, Mai-Geng Zhou, Bing-Xin Ji, Peng Yin   +7 more
doaj   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Identify Sensitive Periods for Onset and Resolution of Hypertension and Its Subtypes Over the Lifespan

The Journal of Clinical Hypertension
Hypertension represents a significant public health issue globally, yet the age‐related changes in prevalence and transition patterns of blood pressure (BP) categories and hypertension subtypes throughout the lifespan remain unclear.
Xin Meng, Chaonan Gao, Jingfan Xiong, QianJin Qi, Wei Liu, Yongxi Xue, Hongbo Dong, Jie Mi, Yinkun Yan   +8 more
doaj   +1 more source

Hemipteran vectors of stylet‐borne plant viruses: Aphids lead the charge

Insect Science, EarlyView.
Among all sap‐feeding hemipterans, aphids stand out by far as the most important vectors of noncirculative plant viruses. Compared to whiteflies and mealybugs, aphids’ highly specialized stylet anatomy and distinct feeding behaviors contribute, together with other features of their biology, to their remarkable efficiency in transmitting stylet‐borne ...
Yu Fu, Stefano Colella, Marilyne Uzest
wiley   +1 more source