BACKGROUND: Almost all patients with Duchenne muscular dystrophy (DMD) eventually develop respiratory failure. Once 24 h ventilation is required, either due to incomplete effectiveness of nocturnal noninvasive ventilation (NIV) or bulbar weakness, it is ...
Douglas A McKim +4 more
doaj +1 more source
The Use of Noninvasive Mechanical Ventilation in Myasthenic Crisis
Myasthenia gravis is an autoimmune disease of the nicotinic acetylcholin receptors at the postsynaptic membrane of the neuromuscular junction. Myasthenic crisis, defined as respiratory failure requiring mechanical ventilation is a common life-threatening
Mustafa Said Aydoğan +6 more
doaj +1 more source
Timing of Intubation in COVID-19: When It Is Too Early and When It Is Too Late
The timing of initiating mechanical ventilation in patients with acute respiratory distress syndrome due to COVID-19 remains controversial. At the outset of the pandemic, “very early” intubation was recommended in patients requiring oxygen flows above 6 ...
John C. Grotberg, MD, Bryan D. Kraft, MD
doaj +1 more source
FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang +15 more
wiley +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Noninvasive ventilation in pediatrics
To introduce the notion of noninvasive mechanical ventilation as an alternative for invasive ventilation in children, describing advantages and disadvantages, indications, and the process of equipment installation.Literature review through PubMed/Medline, using as source articles focusing on noninvasive ventilation in pediatric populations, as well as ...
Dafne Cardoso Bourguignon, da Silva +2 more
openaire +2 more sources
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu +11 more
wiley +1 more source
Noninvasive ventilation in children [PDF]
The use of noninvasive ventilation (NIV)/ventilatory assistance has in its modern form experienced a resurgence during the last two decades, primarily in the adult population.During the last few years, NIV, predominantly in the form of positive-pressure ventilation/ventilatory assistance, has also become an option in the paediatric population. Although
openaire +2 more sources
Mechanical ventilation in chronic obstructive pulmonary disease patients, noninvasive vs. invasive method (randomized prospective study) [Usporedba neinvazivne i invazivne umjetne ventilacije kod bolesnika s kroničnom opstruktivnom plućnom bolesti: prospektivna randomizirana studija] [PDF]
Acute respiratory failure due to chronic obstructive pulmonary disease (COPD) presents an increasing problem throughout the world. The aim of this study was to compare invasive and non-invasive mechanical ventilation (MV) for patients with COPD.
Buković, Damir +5 more
core
Unveiling Localized Heat in Lithium‐Ion Cells for Intelligent Temperature Sensing
Heat generation, thermal responses, and intelligent management in batteries. Lithium‐ion batteries (LIBs) power electric vehicles, portable electronics, and grid‐scale storage, yet their safety, performance, and lifetime are constrained by thermal effects.
Yunke Wang +6 more
wiley +1 more source

