Results 41 to 50 of about 1,258,536 (319)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Efficient high-order finite difference methods for nonlinear Klein–Gordon equations. I: Variants of the phi-four model and the form-I of the nonlinear Klein–Gordon equation

, 2015
In this paper, the problem of solving some nonlinear Klein–Gordon equations (KGEs) is considered. Here, we derive different fourth- and sixth-order explicit and implicit algorithms to solve the phi-four equation and the form-I of the nonlinear Klein ...
Queiruga-Dios, Araceli, Gayoso-Martínez, Víctor, Martín-Vaquero, Jesus, Encinas, Ascensión Hernández Hernández   +3 more
core   +1 more source

Finite-time stochastic input-to-state stability and observer-based controller design for singular nonlinear systems

, 2020
This paper investigated observer-based controller for a class of singular nonlinear systems with state and exogenous disturbance-dependent noise. A new sufficient condition for finite-time stochastic input-to-state stability (FTSISS) of stochastic ...
Cao, Jinde, Zhao, Feng, Chen, Xiangyong, Qiu, Jianlong, Guo, Ming   +4 more
core   +1 more source

High-contrast and reversible scattering switching via hybrid metal-dielectric metasurfaces

Beilstein Journal of Nanotechnology, 2018
Novel types of optical hybrid metasurfaces consist of metallic and dielectric elements are designed and proposed for controlling the interference between magnetic and electric modes of the system, in a reversible manner.
Jonathan Ward, Khosro Zangeneh Kamali, Lei Xu, Guoquan Zhang, Andrey E. Miroshnichenko, Mohsen Rahmani   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The passivity of adaptive output regulation of nonlinear exosystem with application of aircraft motions

, 2017
This paper deals with passivity of adaptive output regulation of nonlinear exosystem. It is shown that factorisable low-high frequency gains and harmonic uncertainties are estimated to the exogenous signals with adaptive nonlinear system.
Kumar, R. Ravi Ravi, Cao, Jinde, Alsaedi, Ahmad   +2 more
core   +1 more source

Acoustic Phonon Wave Attenuation in One-Dimensional Antiferromagnet: Effects of DM Interaction on Magnon-Phonon Coupling Factor

Advances in Condensed Matter Physics
The study of one-dimensional (1D) multiferroic spin chain systems exhibiting magnetoelectric coupling continues to be a primary emphasis in condensed matter physics.
Erna Leticia Tchinda Ngounou, Blaise Ndakom, Adrien Yvan Nouboudem Tchinda, Engelberg Afuoti Ngwa, Georges Collince Fouokeng, Nadjitonon Ngarmaim, Aurélien Kenfack-jiotsa   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Perturbation solutions of fifth order oscillatory nonlinear systems

, 2011
Oscillatory systems play an important role in the nature. Many engineering problems and physical systems of fifth degrees of freedom are oscillatory and their governing equations are fifth order nonlinear differential equations.
Akbar, M. Ali Ali, Siddique, Sk. Tanzer Ahmed Ahmed   +1 more
core   +1 more source

An improved adaptive fuzzy backstepping control for nonlinear mechanical systems with mismatched uncertainties

Automatika, 2019
When the nonlinear mechanical system has mismatched uncertainties, it is difficult to design control algorithm to achieve high precision trajectory tracking control.
Wan Min, Qingyou Liu
doaj   +1 more source