Results 61 to 70 of about 1,264,156 (319)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Modeling and prescribed H-infinity tracking control for strict feedback nonlinear systems [PDF]
, 2017 By utilizing backstepping technique, an H∞ robust controller with improved prescribed performance and dynamic surface control is designed for a class of strict feedback nonlinear systems.
Chen, Ming +3 more
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Nonlinear generalized cyclic contractions in complete G-metric spaces and applications to integral equations [PDF]
, 2013 In this paper we introduce generalized cyclic contractions in G-metric spaces and establish some fixed point theorems. The presented theorems extend and unify various known fixed point results. Examples are given in the support of these results.
Kadelburg, Zoran +1 more
core +2 more sources
High Sensitivity Integrated Visible to Mid-Infrared Nonlinear Plasmonic Sensor
IEEE Photonics Journal, 2017 We propose a Kretschmann-based nonlinear plasmonic sensor with a gold thin film deposited on a glass prism. Visible and mid-infrared signals are generated in this configuration through the nonlinear processes of sum- and difference-frequency generation ...
F. Che +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Numerical Analysis of Time-Accurate Solution of Nonlinear Flow Models by Implicit Finite Differences [PDF]
, 2003 Implicit finite differences are often applied to solve flow models. A standard technique to solve these equations is Newton\u27s method. lf time step is too large although the difference equation could be computationally stable, Newton\u27s method may ...
Dey, S. K.
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A nonlinear control system with a Hilfer derivative and its optimization [PDF]
, 2019 In this work, we consider a fractional optimal control problem (FOCP) containing a nonlinear control system, described by a differential equation involving a Hilfer derivative, and an integral cost functional.
Kamocki, Rafał
core +2 more sources
Multi-μJ 12 μm Femtosecond GaSe-based OPCPA at 1 kHz Repetition Rate [PDF]
EPJ Web of Conferences, 2022 Fuertjes Pia +4 more
doaj +1 more source