Results 41 to 50 of about 157,302 (264)

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

$\mathcal {H}_{2}$- and $\mathcal {H}_\infty$-Optimal Model Predictive Controllers for Robust Legged Locomotion

IEEE Open Journal of Control Systems
This paper formally develops robust optimal predictive control solutions that can accommodate disturbances and stabilize periodic legged locomotion.
Abhishek Pandala, Aaron D. Ames, Kaveh Akbari Hamed   +2 more
doaj   +1 more source

Constrained controllability of nonlinear systems [PDF]

Proceedings of the 2003 American Control Conference, 2003., 1995
This paper contains constrained exact local controllability results for nonlinear abstract differential equations. A generalization of the open mapping theorem is used for the sufficient conditions to guarantee controllability. The values of controls are in a convex, closed cone with vertex at 0.
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Tuning and Feasibility Analysis of Classical First-Order MIMO Non-Linear Sliding Mode Control Design for Industrial Applications

Machines, 2019
Model-based control techniques have been gaining more and more interest these days. These complex control systems are mostly based on theories, such as feedback linearization, model predictive control, adaptive and robust control.
Alessandro Palmieri, Renato Procopio, Andrea Bonfiglio, Massimo Brignone, Marco Invernizzi, Andrea Morini, Boban Veselic’   +6 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Hysteresis Quantizer-Based Event-Triggered Control of Nonlinear Networked Control Systems

IEEE Access, 2019
In this paper, we present a novel event-triggered control mechanism for nonlinear systems with hysteresis quantization. To describe the tendency of the dynamic quantizer parameter, an auxiliary parameter is created and the relationship between the ...
Tianwei Zhou, Tao Zhou
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Experimental analysis of passivity‐based control theory for permanent magnet synchronous motor drive fed by grid power

IET Control Theory & Applications
Controlling the Permanent Magnet Synchronous Motor (PMSM) can be challenging due to the nonlinearity of its dynamics, which makes it difficult to design control strategies that are both robust and effective. To address this challenge, this paper presents
Youcef Belkhier, Achour Abdelyazid, Adel Oubelaid, Nima Khosravi, Mohit Bajaj, Pradeep Vishnuram, Ievgen Zaitsev   +6 more
doaj   +1 more source