Results 41 to 50 of about 975,613 (342)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Controller performance design and assessment using nonlinear generalized minimum variance benchmark : scalar case [PDF]

open access: yes, 2004
A nonlinear version of the Generalized Minimum Variance (GMV) multivariable control law has been recently derived for the control of nonlinear, possibly time-varying systems.
Grimble, M.J., Majecki, P.M.
core  

Thomas decompositions of parametric nonlinear control systems

open access: yes, 2012
This paper presents an algorithmic method to study structural properties of nonlinear control systems in dependence of parameters. The result consists of a description of parameter configurations which cause different control-theoretic behaviour of the ...
Lange-Hegermann, Markus, Robertz, Daniel
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Prescribed-time control of stochastic high-order nonlinear systems

open access: yesMathematical Biosciences and Engineering, 2022
In this paper, the prescribed-time stabilization is studied for stochastic high-order nonlinear systems. Different from the previous research results on stochastic high-order nonlinear systems where only asymptotic stabilization or finite-time ...
Hui Wang
doaj   +1 more source

ℋ∞ control of nonlinear systems via output feedback: controller parameterization [PDF]

open access: yes, 1994
The standard state space solutions to the ℋ∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems. A class of local nonlinear (output feedback) ℋ∞ controllers are parameterized as nonlinear fractional ...
Doyle, John C., Lu, Wei-Min
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Tracking Control for Nonlinear Networked Control Systems [PDF]

open access: yesIEEE Transactions on Automatic Control, 2014
We investigate the tracking control of nonlinear networked control systems (NCS) affected by disturbances. We consider a general scenario in which the network is used to ensure the communication between the controller, the plant and the reference system generating the desired trajectory to be tracked.
Postoyan, R   +3 more
openaire   +3 more sources

3 sampled-data control of nonlinear systems

open access: yes, 2006
This chapter provides some of the main ideas resulting from recent developments in sampled-data control of nonlinear systems. We have tried to bring the basic parts of the new developments within the comfortable grasp of graduate students.
Astolfi, Alessandro   +2 more
core   +1 more source

Geometric numerical integration of nonholonomic systems and optimal control problems [PDF]

open access: yes, 2002
A geometric derivation of numerical integrators for nonholonomic systems and optimal control problems is obtained. It is based in the classical technique of generating functions adapted to the special features of nonholonomic systems and optimal control ...
de Diego, D. Martin   +2 more
core   +2 more sources

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