Results 41 to 50 of about 945,100 (334)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

ℋ∞ control of nonlinear systems via output feedback: controller parameterization [PDF]

, 1994
The standard state space solutions to the ℋ∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems. A class of local nonlinear (output feedback) ℋ∞ controllers are parameterized as nonlinear fractional ...
Doyle, John C., Lu, Wei-Min
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

H∞ Control of Nonlinear Systems: A Class of Controllers [PDF]

, 1993
The standard state space solutions to the H∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems.
Doyle, John C., Lu, Wei-Min
core  

Geometric numerical integration of nonholonomic systems and optimal control problems [PDF]

, 2002
A geometric derivation of numerical integrators for nonholonomic systems and optimal control problems is obtained. It is based in the classical technique of generating functions adapted to the special features of nonholonomic systems and optimal control ...
de Diego, D. Martin, de Leon, M., Merino, A. Santamaria   +2 more
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Prescribed-time control of stochastic high-order nonlinear systems

Mathematical Biosciences and Engineering, 2022
In this paper, the prescribed-time stabilization is studied for stochastic high-order nonlinear systems. Different from the previous research results on stochastic high-order nonlinear systems where only asymptotic stabilization or finite-time ...
Hui Wang
doaj   +1 more source

3 sampled-data control of nonlinear systems

, 2006
This chapter provides some of the main ideas resulting from recent developments in sampled-data control of nonlinear systems. We have tried to bring the basic parts of the new developments within the comfortable grasp of graduate students.
Astolfi, Alessandro, Laila, Dina Shona, Nesic, Dragan   +2 more
core   +1 more source

Mathematical control of complex systems 2013 [PDF]

, 2014
Mathematical control of complex systems have already become an ideal research area for control engineers, mathematicians, computer scientists, and biologists to understand, manage, analyze, and interpret functional information/dynamical behaviours from ...
Dong, H, He, X, Hu, J, Karimi, HR, Shen, B, Wang, Z   +5 more
core   +4 more sources