Results 31 to 40 of about 22,994 (260)

Mathematical modelling of the elastic behavior of structured geophysical media

open access: yesГеофизический журнал, 2017
Article is retracted From the viewpoint of modern concepts of nonlinear geophysics, the presence of the hierarchical block structure, anisotropy and heterogeneities is the defining property of the natural medium in particular of the Earth’s crust.
N. V. Olali   +2 more
doaj   +1 more source

Controllability for systems governed by semilinear evolution equations without compactness [PDF]

open access: yes, 2014
We study the controllability for a class of semilinear differential inclusions in Banach spaces. Since we assume the regularity of the nonlinear part with respect to the weak topology, we do not require the compactness of the evolution operator generated
Benedetti, Irene   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Modelling of Phase Separation in Alloys with Coherent Elastic Misfit

open access: yes, 1998
Elastic interactions arising from a difference of lattice spacing between two coherent phases can have a strong influence on the phase separation (coarsening) of alloys.
Fratzl, P., Lebowitz, J. L., Penrose, O.
core   +2 more sources

Nonlinear second-order multivalued boundary value problems [PDF]

open access: yes, 2003
In this paper we study nonlinear second-order differential inclusions involving the ordinary vector $p$-Laplacian, a multivalued maximal monotone operator and nonlinear multivalued boundary conditions.
Gasinski, Leszek   +1 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Nonlinear Volterra integrodifferential evolution inclusions and optimal control [PDF]

open access: yesKodai Mathematical Journal, 1991
Volterra integrodifferential evolution inclusions of nonconvolutory type with time dependent unbounded operators and with both convex and nonconvex multivalued perturbations are studied. The results obtained are applied to distributed parameter optimal control problems. By assuming suitable assumptions on the operator \(A\) and on the multifunction \(F\
openaire   +3 more sources

Nonlinear Volterra delay evolution inclusions subjected to nonlocal initial conditions

open access: yesTopological Methods in Nonlinear Analysis, 2021
This paper deals with a nonlinear Volterra delay evolution inclusion subjected to a nonlocal implicit initial condition. The evolution inclusion involves an $m$-dissipative operator (possibly multivalued and/or nonlinear) and a noncompact interval. We first consider the evolution inclusion subjected to a local initial condition and prove an existence ...
Yu, Yang-Yang   +2 more
openaire   +2 more sources

Evolutionary Oseen model for generalized Newtonian fluid with Multivalued Nonmonotone Friction Law [PDF]

open access: yes, 2018
The paper deals with the non-stationary Oseen system of equations for the generalized Newtonian incompressible fluid with multivalued and nonmonotone frictional slip boundary conditions.
Dudek, Sylwia, Migórski, Stanisław
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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