Results 31 to 40 of about 1,556 (222)
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Electronic Journal of Differential Equations, 2002 We apply Monch type fixed point theorems for acyclic multivalued maps to the solvability of inclusions of Hammerstein type in Banach spaces. Our approach makes possible to unify and improve the existence theories for nonlinear evolution problems and ...
Jean-Francois Couchouron, Radu Precup
doaj
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Topological properties of the solution set of a class of nonlinear evolutions inclusions [PDF]
Czechoslovak Mathematical Journal, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Exact controllability for nonlocal semilinear differential inclusions
Bruno Pini Mathematical Analysis SeminarIn this paper, we investigate the controllability of a class of semilinear differential inclusions in Hilbert spaces. Assuming the exact controllability of the associated linear problem, we establish sufficient conditions for achieving the exact ...
Irene Benedetti, Angelica Palazzoni
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Inhomogeneities in Glass: From Defects to Functional Nanostructures
EncyclopediaGlass inhomogeneities represent variations in the structural or compositional uniformity of glass, traditionally associated with process-related defects such as striae, bubbles, stones, and inclusions that impair transparency and mechanical stability ...
Georgiy Yu. Shakhgildyan +1 more
doaj +1 more source
Anti-periodic extremal problems for a class of nonlinear evolution inclusions in R N [PDF]
Journal of Inequalities and Applications, 2014 From the abstract: ``The aim of this paper is to establish the existence of anti-periodic solutions to the following nonlinear anti-periodic problem: \[ \begin{gathered}\dot{x}+A(t,x)\in Ext F(t,x) \text{ a.e. } t\in I, \\ x(T)=-x(0)\end{gathered} \] in \(\mathbb R^n\), where \(Ext F(t,x)\) denotes the extremal point set of the multifunction \(F(t,x)\),
Zhang, Jingrui +3 more
openaire +2 more sources
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source