Results 31 to 40 of about 1,819 (252)

Periodic solutions for nonlinear nonmonotone evolution inclusions

Discrete and Continuous Dynamical Systems - B, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gasiński, Leszek, Papageorgiou, Nikolaos S.   +1 more
openaire   +4 more sources

Periodic Solutions For Nonlinear Evolution Inclusions [PDF]

, 1996
In this paper we prove the existence of periodic solutions for a class of nonlinear evolution inclusions defined in an evolution triple of spaces (X;H;X*) and driven by a demicontinuous pseudomonotone coercive operator and an upper semicontinuous ...
Papageorgiou, N, Kandilakis, Dimitrios A., Papageorgiou, Nikolaos S., Dimitrios A. Kandilakis, Nikolaos S. Papageorgiou, Dimitrios, A   +5 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Anti-periodic solutions for nonlinear evolution inclusions

Journal of Evolution Equations, 2018
The authors consider the nonlinear anti-periodic evolution inclusion \[ \begin{aligned} & -u'(t)\in A(t,u(t))+F(t,u(t))\text{ a.e. on }I=[0,T],\\ & u(0)=-u(T),\end{aligned}\eqno{(1)} \] where \(\left( X,H,X^{\ast }\right) \) is an evolution triple, \(A:I\times X\rightarrow 2^{X^{\ast }}\) and \(F:I\times X\rightarrow 2^{H}\). \ It is not assumed that \(
Gasiński, Leszek, Papageorgiou, Nikolaos S.   +1 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Existence of extremal periodic solutions for nonlinear evolution inclusions [PDF]

, 2001
summary:We consider a nonlinear evolution inclusion defined in the abstract framework of an evolution triple of spaces and we look for extremal periodic solutions. The nonlinear operator is only pseudomonotone coercive.
Papageorgiou, Nikolaos S., Yannakakis, Nikolaos   +1 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Strong nonlinear functional-differential variational inequalities: problems without initial conditions

Frontiers in Applied Mathematics and Statistics
Problems without initial conditions for evolution equations and variational inequalities appear in the modeling of different non-stationary processes within many fields of science, such as ecology, economics, physics, cybernetics, etc., if these ...
Mykola Bokalo, Iryna Skira, Taras Bokalo
doaj   +1 more source

On the “bang-bang” principle for nonlinear evolution inclusions

Aequationes Mathematicae, 1993
This paper appears to be (verbatim) the same as [Aequationes Math. 45, No. 2-3, 267-280 (1993) see the review above].
openaire   +2 more sources