Results 41 to 50 of about 1,819 (252)
Galerkin approximations for nonlinear evolution inclusions [PDF]
, 1994 summary:In this paper we study the convergence properties of the Galerkin approximations to a nonlinear, nonautonomous evolution inclusion and use them to determine the structural properties of the solution set and establish the existence of periodic ...
Hu, Shouchuan +3 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On the set of solutions of a class of nonlinear evolution inclusions [PDF]
Kodai Mathematical Journal, 1992 The present paper deals with properties of the solution set of the Cauchy problem for nonlinear evolution inclusions of the form \(x'(t)\in A(t,x(t))+f(t)\), a.e., and \(x'(t)\in A(t,x(t))+F(t,x(t))\), a.e., where \(A\) and \(F\) are multivalued mappings.
openaire +2 more sources
Electronic Journal of Differential Equations, 2002 We apply Monch type fixed point theorems for acyclic multivalued maps to the solvability of inclusions of Hammerstein type in Banach spaces. Our approach makes possible to unify and improve the existence theories for nonlinear evolution problems and ...
Jean-Francois Couchouron, Radu Precup
doaj
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Nonlinear boundary value problems for second order differential inclusions [PDF]
, 2001 summary:In this paper we study two boundary value problems for second order strongly nonlinear differential inclusions involving a maximal monotone term.
Matzakos, Nikolaos +7 more
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Exact controllability for nonlocal semilinear differential inclusions
Bruno Pini Mathematical Analysis SeminarIn this paper, we investigate the controllability of a class of semilinear differential inclusions in Hilbert spaces. Assuming the exact controllability of the associated linear problem, we establish sufficient conditions for achieving the exact ...
Irene Benedetti, Angelica Palazzoni
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source