Results 51 to 60 of about 746,112 (330)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Evaluation of Advanced Nonlinear Static Procedure [PDF]

Journal of Structural and Construction Engineering, 2015
Having very simplicity, nonlinear static procedures (NSPs) are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the
Mohsen Ali Shayanfar, Reza ZareBidoki
doaj  

Attractor reconstruction of an impact oscillator for parameter identification [PDF]

, 2015
Peer ...
Baptista, Murilo Da Silva, Ing, James, Sayah, Mukthar, Wiercigroch, Marian   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Seismic Performance Evaluation of Multi-Storey Residential Building with Friction Pendulum Bearings: Indonesia case study

Structural Mechanics of Engineering Constructions and Buildings
The methodology for seismic performance evaluation of a residential building in Indonesia with the use of seismic isolation is considered. An 8-storey reinforced concrete frame residential building with shear wall structural system was selected as a case
Zaurbek K. Abaev, Faiz Sulthan
doaj   +1 more source

The Effect of Spandrel Beam's Specification on Response Modification Factor of Concrete Coupled Shear Walls [PDF]

Civil Engineering Infrastructures Journal, 2016
Response modification factor (R factor) is one of the seismic design parameters to be considered in evaluating the performance of buildings during strong motions. This paper has tried to evaluate the response modification factor of concrete coupled shear
Mussa Mahmoudi, seyed Mohammad Reza Mortazavi, Saeid Ajdari   +2 more
doaj   +1 more source

Analysis of Retrofit Building Behavior with Base Isolation System Using Nonlinear Time History Analysis

IPTEK Journal of Proceedings Series, 2017
Now,  procedures of design for the earthquake resistance of buildings and non-building structures SNI 1726: 2012 has been approved the procedures for seismic design for buildings SNI 1726-2002.  SNI 1726: 2012 refers to the development  of  modern seismic regulations are due to changes in tectonic plates located on the active track on the path of ...
Yanisfa Septiarsilia, Tavio Tavio, I Gusti Putu Raka   +2 more
openaire   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Effect of U-Shaped Metallic Dampers on the Seismic Performance of Steel Structures based on Endurance-Time Analysis

Buildings
Seismic performance of steel moment-resisting frames is investigated through the incorporation of U-shaped metallic dampers. The primary objective is to assess the effectiveness of these dampers in mitigating seismic responses by utilizing various ...
Farhad Farajiani, Farzaneh Elyasigorji, Sina Elyasigorji, Mohammad Javad Moradi, Visar Farhangi   +4 more
doaj   +1 more source

Nonlinear Response and Collapse Analysis of Double-Channel Aqueduct under Strong Earthquake

Advances in Civil Engineering, 2022
As a common water conveyance structure, aqueduct is widely used in cross-regional water conveyance and diversion projects. However, large double-trough aqueduct structures are prone to damage under earthquake, resulting in water leakage and even ...
Chong Wu, Jinpeng Zhang, Jianguo Xu, Chunyu Zhang, Yupeng Geng   +4 more
doaj   +1 more source