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Measurement of Nonmotor Symptoms in Clinical Practice
2017Nonmotor symptoms constitute a prominent part of Parkinson's disease manifestations. They are present since the first phases of the disease, increase their number and severity with disease progression, and importantly impact on patients' health and quality of life, caregivers' burden, and social resources.
Pablo, Martinez-Martin +4 more
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Biomarkers of Nonmotor Symptoms in Parkinson's Disease
2017Biomarkers are helpful for early diagnosis, assessment of disorder severity, prognosis, and prediction of response to therapy. Given that early therapeutic intervention may be useful in forestalling or slowing neurodegenerative conditions, employing reliable biomarkers to identify asymptomatic individuals who are destined to develop clinical Parkinson ...
Takuya, Konno +3 more
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Imaging the Nonmotor Symptoms in Parkinson's Disease
2017Parkinson's disease is acknowledged to be a multisystem syndrome, manifesting as a result of multineuropeptide dysfunction, including dopaminergic, cholinergic, serotonergic, and noradrenergic deficits. This multisystem disorder ultimately leads to the presentation of a range of nonmotor symptoms, now appreciated to be an integral part of the disease ...
Yousaf, Tayyabah +2 more
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Treatment of Nonmotor Symptoms Associated with Parkinson Disease
Neurologic Clinics, 2020Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease.
Jennifer G, Goldman +1 more
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The impact of nonmotor symptom burden on sexual function
2022Sexual dysfunction (SD) is defined as a combination of reduction in libido, and problems with a person's ability to have sex. It is a frequent but neglected and poorly recognized nonmotor symptom (NMS) in Parkinson's disease (PD) which correlates with reduced quality of life (QoL).
Juliet, Staunton +3 more
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The Gut and Nonmotor Symptoms in Parkinson's Disease
2017Gastrointestinal (GI) symptoms are one of the most common nonmotor symptoms (NMS) in patients with Parkinson's disease (PD) involving the whole GI tract (GIT) and being evident throughout the whole course of the disease. Furthermore, constipation serves as a risk factor for PD as well as an early prodromal NMS of PD.
Lisa, Klingelhoefer, Heinz, Reichmann
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Nutrition and Nonmotor Symptoms of Parkinson's Disease
2017To date, no guidelines exist for the screening, evaluation, and management of nutritional status in PD. Dozens of studies demonstrate an association between diet in adulthood with subsequent risk of developing PD. Individuals with PD are at increased risk of malnutrition due to the increased metabolic demands and disease pathophysiology.
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Neuropathology of Nonmotor Symptoms of Parkinson's Disease
2017Parkinson's disease (PD), a multiorgan neurodegenerative disorder associated with α-synuclein deposits throughout the nervous system and many organs, is clinically characterized by motor and nonmotor features, many of the latter antedating motor dysfunctions by 20 or more years.
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Nonmotor Symptoms in Experimental Models of Parkinson's Disease
2017Nonmotor symptoms of Parkinson's disease (PD) range from neuropsychiatric, cognitive to sleep and sensory disorders and can arise from the disease process as well as from drug treatment. The clinical heterogeneity of nonmotor symptoms of PD is underpinned by a wide range of neuropathological and molecular pathology, affecting almost the entire range of
Titova, Nataliya +5 more
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Quality of Life and Nonmotor Symptoms in Parkinson's Disease
2017Health-related quality of life (HRQoL) is defined as "the perception and evaluation by patients themselves of the impact caused on their lives by the disease and its consequences." HRQoL is conceptualized as a combination of physical, psychological, and social well-being in the context of a particular disease. Following earlier studies revolving on the
Erro, Roberto +2 more
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