Results 61 to 70 of about 9,757 (189)

Semen Quality and DNA Fragmentation After Limited Testicular Sperm Extraction in Non‐Azoospermic Men With ART Failure: A Retrospective Matched Cohort Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Testicular sperm extraction (TESE) is sometimes used in non‐azoospermic men with persistent infertility, particularly in cases of high sperm DNA fragmentation index (DFI) or repeated intracytoplasmic sperm injection (ICSI) failure.
Naser Amirjannati, Hamed Akhavizadegan, Arash Mohazzab, Negin Amirjannati, Manizheh Fathalian, Ghazaleh Eslamian   +5 more
wiley   +1 more source

Scrotal US for evaluation of infertile men with azoospermia

, 2006
PURPOSE: To evaluate prospectively the accuracy of scrotal ultrasonography (US) in distinguishing obstructive azoospermia from nonobstructive azoospermia in infertile men by using histologic findings as the reference standard.
Cho, Jeong Yeon, Chun, Yi Kyeong, Kim, Seung Hyup, Moon, Min Hoan, Seo, Ju Tae   +4 more
core   +1 more source

SPARK: A webserver for comprehensive search and analysis of testicular single‐cell transcriptomic data covering full lifecycle and pathology

iMetaOmics, Volume 3, Issue 2, June 2026.
SPARK is an interactive platform hosting 189,232 human testicular single‐cell transcriptomes across normal and infertile conditions. It enables automated, code‐free analysis and visualization, providing a powerful resource to explore cellular and molecular dynamics in male reproduction and infertility.
Lina Cui, Xiaojian Lu, Hui Cai, Ziyan Zhuang, Yifei Guo, Qiaoling Jiang, Zhe Zhang, Hui Jiang, Xiaoyan Wang, Jingtao Guo   +9 more
wiley   +1 more source

Hormonal Therapy Before Micro‐TESE in Men With Nonobstructive Azoospermia: A Negative Answer to an Overly Broad Question

Andrology, EarlyView.
Sandro C. Esteves, Arnold P. P. Achermann, Ricardo Miyaoka, Cassio L. Z. Riccetto, Adriano Fregonesi   +4 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Emerging trends in the management of non‐obstructive azoospermia

UroPrecision
Ten percent of infertile males have azoospermia, classified into obstructive and nonobstructive types, which require specific medical or surgical treatments.
Mina Saad, Mohamed Alkabeer, Dina Abdelmonim, Sameh Fayek GamalElDin, Mohamed Wael Ragab   +4 more
doaj   +1 more source

Author's Response: Can Hormonal Therapy Improve the Outcomes of mTESE in Patients with Nonobstructive Azoospermia?

Andrology, EarlyView.
M. Anfosso, M. Schubert, JF. Cremers, S. Kliesch, M. Zitzmann, S. Bier   +5 more
wiley   +1 more source

Mutation in MSH5 Causes Primary Ovarian Insufficiency and Successful Therapeutic Intervention by In Vitro Fertilisation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Primary ovarian insufficiency (POI) is a genetically heterogeneous disorder characterised by cessation of menstruation before the age of 40 years with elevated levels of follicle‐stimulating hormone. Germline variants in the MSH5 gene cause POI. In this study, we investigated a Han Chinese family with POI.
Bin Mao, Lili Zhang, Xiaodong Zhao, Xiaojuan Xu, Hongfang Liu, Dexiao Song, Peiqiang Li, Santasree Banerjee, Xiaoling Ma, Yongxiu Yang   +9 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Reinke’s crystals in perivascular and peritubular Leydig cells of men with nonobstructive and obstructive azoospermia: a retrospective case-control study [PDF]

, 2019
Aim To analyze the differences in the population of perivascular and peritubular Leydig cells (LC) and the number of Reinke’s crystals (RCs) in the testicles of infertile men with non-obstructive and obstructive azoospermia.
Di Luca, Monica
core   +1 more source