Results 41 to 50 of about 263,405 (267)

Bandwidth Selection in Nonparametric Regression with Large Sample Size

Proceedings, 2018
In the context of nonparametric regression estimation, the behaviour of kernel methods such as the Nadaraya-Watson or local linear estimators is heavily influenced by the value of the bandwidth parameter, which determines the trade-off between bias and ...
Daniel Barreiro-Ures, Ricardo Cao, Mario Francisco-Fernández   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Distribution and Quantiles of Sample Autocovariances and Autocorrelations of Sample Moments from a Stationary Process

Axioms
This paper gives expansions for the distribution, density and quantiles of any estimate that is a smooth function of the sample cross-moments of a stationary process.
Christopher Stroude Withers
doaj   +1 more source

Nonparametric sparsity and regularization

J. Mach. Learn. Res., 2012
45 pages, 11 ...
ROSASCO, LORENZO, VILLA, SILVIA, MOSCI, SOFIA, M. Santoro, A. Verri   +4 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Simultaneous optimization of shape and topology for solid structure (Proposal of a topology optimization method with variable design domain)

Nihon Kikai Gakkai ronbunshu
Since the optimization results obtained by topology optimization depend on the size of the design domain, it is desirable to optimize the design domain as well during topology optimization.
Daiki YAMANE, Masatoshi SHIMODA
doaj   +1 more source

Spatially Dependent Bayesian Modeling of Geostatistics Data and Its Application for Tuberculosis (TB) in China

Mathematics, 2023
Geostatistics data in regions always have highly spatial heterogeneous, yet the regional features of the data itself cannot be ignored. In this paper, a novel latent Bayesian spatial model is proposed, which incorporates the spatial dependence of ...
Zongyuan Xia, Bo Tang, Long Qin, Huiguo Zhang, Xijian Hu   +4 more
doaj   +1 more source

Nonparametric analysis of covariance [PDF]

The Annals of Statistics, 2001
In the problem of testing the equality of k regression curves from independent samples we discuss three methods using nonparametric estimation techniques of the regression function. The first test is based on a linear combination of estimators for the integrated variance function in the individual samples and in the combined sample. The second approach
Dette, Holger, Neumeyer, Natalie
openaire   +4 more sources

Comparison the Robust Estimators Nonparametric of Nonparametric Regressions

Tikrit Journal of Pure Science, 2023
In order to get rid of or reduce the abnormal values ​​of some phenomena that may be the reason for not obtaining the desired results. This makes us to get conclusions far from reality for the phenomenon we are studying. That the traditional nonparametric estimators are very sensitive to anomalous values, which prompted us to use the fortified ...
Ali Fadhil Abduljabbar, Afrah Mohammed Kadhim   +1 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source