Results 61 to 70 of about 624,838 (295)
Review of Economic Perspectives, 2020 In many OECD countries, changes in demography and health conditions are putting pressure on public finance. To prevent further expansion of government spending as a percentage of GDP, public spending efficiency will need to be raised.
Dutu Richard, Sicari Patrizio
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Consistent estimation of the filtering and marginal smoothing distributions in nonparametric hidden Markov models [PDF]
, 2015 In this paper, we consider the filtering and smoothing recursions in nonparametric finite state space hidden Markov models (HMMs) when the parameters of the model are unknown and replaced by estimators.
Corff, Sylvain Le +2 more
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Entropy, 2018 The Sharpe ratio is a widely used risk-adjusted performance measurement in economics and finance. Most of the known statistical inferential methods devoted to the Sharpe ratio are based on the assumption that the data are normally distributed.
Yuejiao Fu +2 more
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FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Plug-in Bandwidth Selection for Kernel Density Estimation with Discrete Data
Econometrics, 2015 This paper proposes plug-in bandwidth selection for kernel density estimation with discrete data via minimization of mean summed square error. Simulation results show that the plug-in bandwidths perform well, relative to cross-validated bandwidths, in ...
Chi-Yang Chu +2 more
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Nonparametric Methods in Reliability
Statistical Science, 2004 Probabilistic and statistical models for the occurrence of a recurrent event over time are described. These models have applicability in the reliability, engineering, biomedical and other areas where a series of events occurs for an experimental unit as time progresses.
Hollander, Myles, Peña, Edsel A.
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Ecology and Evolution, 2022 By measuring the temporal consistency, or repeatability, in the diets of predators, we can gain a better understanding of the degree of individual specialization in resource utilization and implications for predator–prey interactions, population dynamics,
Connie Stewart +3 more
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