Results 51 to 60 of about 263,405 (267)
Nonparametric Methods in Reliability
Statistical Science, 2004 Probabilistic and statistical models for the occurrence of a recurrent event over time are described. These models have applicability in the reliability, engineering, biomedical and other areas where a series of events occurs for an experimental unit as time progresses.
Hollander, Myles, Peña, Edsel A.
openaire +3 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Characteristics of balance disorders in patients with white matter hyperintensities
Chinese Journal of Contemporary Neurology and Neurosurgery, 2019 Objective To explore the features of balance disorders in patients with white matter hyperintensity (WMH). Methods The clinical data of 82 patients with WMH from September 2018 to December 2018 were collected. Fazekas scale was used to evaluate the level
Ya⁃qing LI +4 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Improving Bayesian Mixture Models for Multiple Imputation of Missing Data Using Focused Clustering
Revstat Statistical Journal, 2018 We present a joint modeling approach for multiple imputation of missing continuous and categorical variables using Bayesian mixture models. The approach extends the idea of focused clustering, in which one separates variables into two sets before ...
Jerome P. Reiter
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
GMS German Medical Science, 2015 Introduction: For survival data the coefficient of determination cannot be used to describe how good a model fits to the data. Therefore, several measures of explained variation for survival data have been proposed in recent years.Methods: We analyse an ...
Weiß, Verena +2 more
doaj +1 more source
An Information-Based Approach for Mediation Analysis on High-Dimensional Metagenomic Data
Frontiers in Genetics, 2020 The human microbiome plays a critical role in the development of gut-related illnesses such as inflammatory bowel disease and clinical pouchitis. A mediation model can be used to describe the interaction between host gene expression, the gut microbiome ...
Kyle M. Carter +5 more
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
npregfast: An R Package for Nonparametric Estimation and Inference in Life Sciences
Journal of Statistical Software, 2017 We present the R npregfast package via some applications involved with the study of living organisms. The package implements nonparametric estimation procedures in regression models with or without factor-by-curve interactions.
Marta Sestelo +3 more
doaj +1 more source