Results 41 to 50 of about 355,803 (282)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Nonparametric Tests for Scale

open access: yesThe Annals of Mathematical Statistics, 1962
This paper is concerned with two sample rank tests for scale alternatives. The two samples are assumed to have continuous distribution functions with the difference in respective location parameters (medians) known. Various rank tests are considered and compared from the point of view of limiting Pitman efficiency for normal and nonnormal alternatives.
openaire   +3 more sources

Nonparametric Tests for Multivariate Association

open access: yesSymmetry, 2022
Testing the existence of association between a multivariate response and predictors is an important statistical problem. In this paper, we present nonparametric procedures that make no specific distributional, regression function, and covariance matrix assumptions.
Solomon W. Harrar, Yan Xu
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Adaptive Nonparametric Tests for the Generalized Behrens-Fisher Problem

open access: yesAustrian Journal of Statistics, 2016
Some adaptive test procedures are developed for the generalized Behrens-Fisher problem. The one having a deterministic approach is based on calculating a measure of symmetry from each sample and using them as a basis for choosing between the ...
Uttam Bandyopadhyay   +2 more
doaj   +1 more source

Ordinal Cochran-Mantel-Haenszel Testing and Nonparametric Analysis of Variance: Competing Methodologies

open access: yesStats, 2022
The Cochran-Mantel-Haenszel (CMH) and nonparametric analysis of variance (NP ANOVA) methodologies are both sets of tests for categorical response data.
J. C. W. Rayner, G. C. Livingston
doaj   +1 more source

Bayesian nonparametric tests via sliced inverse modeling [PDF]

open access: yes, 2015
We study the problem of independence and conditional independence tests between categorical covariates and a continuous response variable, which has an immediate application in genetics.
Jiang, Bo, Liu, Jun S., Ye, Chao
core  

Consistent tests of conditional moment restrictions [PDF]

open access: yes, 2006
We propose two classes of consistent tests in parametric econometric models defined through multiple conditional moment restrictions. The first type of tests relies on nonparametric estimation, while the second relies on a functional of a marked ...
Delgado, Miguel A.   +2 more
core   +4 more sources

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