Results 51 to 60 of about 355,803 (282)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Non-Parametric Goodness-of-Fit Tests Using Tsallis Entropy Measures
EntropyWe develop goodness-of-fit (GOF) procedures rooted in Tsallis entropy, with a particular emphasis on multivariate exponential-power (generalized Gaussian) and q-Gaussian models. The GOF statistic compares a closed-form Tsallis entropy under the null with
Mehmet Siddik Cadirci
doaj +1 more source
spTest: An R Package Implementing Nonparametric Tests of Isotropy
Journal of Statistical Software, 2018 An important step in modeling spatially-referenced data is appropriately specifying the second order properties of the random field. A scientist developing a model for spatial data has a number of options regarding the nature of the dependence between ...
Zachary D. Weller
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
One-sided and two-sided nonparametric tests for heterogeneity comparisons
Statistica, 2013 This work consists of an inferential procedure that allows for a solution to the problem of hypothesis testing, in which the objective is that of comparing the heterogeneity of two populations on the basis of sampling data, i.e.
Rosa Arboretti Giancristofaro +3 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
BMC Bioinformatics, 2005 Background Numerous nonparametric approaches have been proposed in literature to detect differential gene expression in the setting of two user-defined groups.
Song Peter XK, Gao Xin
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Fundamentals of Nonparametric Statistical Tests for Dental Clinical Research
Dentistry JournalThis article provides the foundation for employing nonparametric testing in dental clinical research. To make wise judgments in their research, investigators should learn more about the main nonparametric tests and their particular uses.
Arturo Garrocho-Rangel +5 more
doaj +1 more source