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Biodegradation of nodularin and other nonribosomal peptides by the Baltic bacteria
International Biodeterioration & Biodegradation, 2018Microcystins (MCs) and nodularin (NOD), the hepatotoxic nonribosomal peptides (NRPs) produced by cyanobacteria, are considered as natural pollutants of many aquatic ecosystems.
Anna Toruńska-Sitarz +2 more
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Nonribosomal peptide synthetases: structures and dynamics
Current Opinion in Structural Biology, 2010Nonribosomal peptide synthetases (NRPSs) are large multimodular biocatalysts that utilize complex regiospecific and stereospecific reactions to assemble structurally and functionally diverse peptides that have important medicinal applications. During this ribosome-independent peptide synthesis, catalytic domains of NRPS select, activate or modify the ...
Matthias, Strieker +2 more
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Adenylation Domains in Nonribosomal Peptide Engineering
ChemBioChem, 2019AbstractNonribosomal peptides are a prolific source of bioactive molecules biosynthesized on large, modular assembly line synthetases. Synthetic biologists seek to obtain tailored peptides with tuned or novel bioactivities by engineering modules and domains of these nonribosomal peptide synthetases.
Aleksa Stanišić, Hajo Kries
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Combinatorial biosynthesis of polyketides and nonribosomal peptides
Current Opinion in Chemical Biology, 2001The engineering of polyketide biosynthesis has begun to provide robust targeted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more structurally diverse libraries have now been demonstrated.
J, Staunton, B, Wilkinson
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A Practical Guideline to Engineering Nonribosomal Peptide Synthetases
2023The bioengineering of nonribosomal peptide synthetases (NRPSs) is a rapidly developing field to access natural product derivatives and new-to-nature natural products like scaffolds with changed or improved properties. However, the rational (re-)design of these often gigantic assembly-line proteins is by no means trivial and needs in-depth insights into
Abbood, N. +3 more
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FRET monitoring of a nonribosomal peptide synthetase
Nature Chemical Biology, 2017Nonribosomal peptide synthetases (NRPSs) are multidomain enzyme templates for the synthesis of bioactive peptides. Large-scale conformational changes during peptide assembly are obvious from crystal structures, yet their dynamics and coupling to catalysis are poorly understood.
Jonas Alfermann +8 more
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Synthesis of the Nonribosomal Peptide Phevalin and Analogs
The Journal of Organic Chemistry, 2019Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described.
Remya Ramesh +3 more
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De Novo Sequencing of Nonribosomal Peptides
2008While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of high-throughput sequencing of NRPs. Difficulties in sequencing NRPs slow down the progress in elucidating the non-ribosomal genetic code and negatively affect various screening programs aimed at the discovery of natural compounds
Nuno Bandeira +5 more
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Metagenome Driven Discovery of Nonribosomal Peptides
ACS Chemical Biology, 2019Declining rates of novel natural product discovery and exponential rates of rediscovery heralded the end of the 1940s to 1960s "golden era" of antibiotic discovery. Fifty years later, the implementation of molecular screening methodologies revealed that standard culture-based screening approaches had failed to capture the vast majority of environmental
Luke J. Stevenson +2 more
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PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases
bioRxivNonribosomal peptides are diverse natural products with important applications in medicine and agriculture. Bacterial and fungal genomes contain thousands of nonribosomal peptide biosynthetic gene clusters (BGCs) of unknown function, providing a ...
B. Terlouw +17 more
semanticscholar +1 more source