Results 171 to 180 of about 5,756 (191)

Biosynthetic engineering of nonribosomal peptide synthetases

Journal of Peptide Science, 2016
From the evolutionary melting pot of natural product synthetase genes, microorganisms elicit antibiotics, communication tools, and iron scavengers. Chemical biologists manipulate these genes to recreate similarly diverse and potent biological activities not on evolutionary time scales but within months. Enzyme engineering has progressed considerably in
openaire   +3 more sources

Peptide Natural Products II: Nonribosomal Peptides

2022
Peptide natural products assembled by nonribosomal peptide synthetase (NRPS) machinery activate proteinogenic and nonproteinogenic amino acids, install them as thioesters tethered to phosphopantetheinyl prosthetic groups on peptidyl carrier protein domains, and carry out chain elongations by amide bond formations.
openaire   +1 more source

Characterization of Nonribosomal Peptide Synthetases with NRPSsp

2016
Bioinformatic sequence analysis allows the functional characterization of newly sequenced proteins. Nonribosomal peptide synthetases (NRPSs) are multi-modular enzymes involved in the biosynthesis of natural products. The current omics era has enabled the exponential growth of the sequenced NRPS, and it is important to characterize the final product of ...
openaire   +2 more sources

Bioinformatics Tools for the Discovery of New Nonribosomal Peptides

2016
This chapter helps in the use of bioinformatics tools relevant to the discovery of new nonribosomal peptides (NRPs) produced by microorganisms. The strategy described can be applied to draft or fully assembled genome sequences. It relies on the identification of the synthetase genes and the deciphering of the domain architecture of the nonribosomal ...
Leclère, Valérie, Weber, Tilmann, Jacques, Philippe, Pupin, Maude   +3 more
openaire   +5 more sources

Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus

Natural Product Research, 2022
Yaojie Guo, Simone Ghidinelli, Mercedes De La Cruz   +2 more
exaly  

Co‐occurring Congeners Reveal the Position of Enantiomeric Amino Acids in Nonribosomal Peptides

ChemBioChem, 2021
Ignacio Pérez-Victoria
exaly  

Global gene-mining strategy for searching nonribosomal peptides as antimicrobial agents from microbial sources

LWT - Food Science and Technology, 2023
Panpan Han, Aijin Ma, Yawei Ning
exaly  

Nonribosomal Peptide Synthesis

2013
Jan Grünewald, Mohamed A. Marahiel
openaire   +1 more source

Nonribosomal Peptide Synthetases

2010
Timothy J. Montavon, Steven D. Bruner
openaire   +1 more source

Single-Molecule Study on Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore

ACS Applied Bio Materials, 2020
Shuo Zhou, Xiaohan Chen, Yunjiao Wang
exaly