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The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases [PDF]
Chemistry and Biology, 1999 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.
Christopher Walsh, David Cane
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Engineering polyketide synthases and nonribosomal peptide synthetases [PDF]
Current Opinion in Structural Biology, 2013 Naturally occurring polyketides and nonribosomal peptides with broad and potent biological activities continue to inspire the discovery of new and improved analogs. The biosynthetic apparatus responsible for the construction of these natural products has been the target of intensive protein engineering efforts. Traditionally, engineering has focused on
Gavin Williams
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Frontiers in Molecular Biosciences, 2020 In nature, various enzymes govern diverse biochemical reactions through their specific three-dimensional structures, which have been harnessed to produce many useful bioactive compounds including clinical agents and commodity chemicals.
Soonkyu Hwang +7 more
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Frontiers in Microbiology, 2019 Identification of novel bioactive compounds represents an important field in modern biomedical research. Microorganisms of the underexplored environments, such as deserts, hot springs, oceans, and caves are highly promising candidates for screening such ...
Dominykas Bukelskis +6 more
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Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis [PDF]
Nature CommunicationsPolyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore +8 more
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Toxins, 2013 Polyketide synthase (PKSs) and nonribosomal peptide synthetase (NRPSs) are large multimodular enzymes involved in biosynthesis of polyketide and peptide toxins produced by fungi.
Massimo Ferrara +2 more
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UMYU Journal of Microbiology Research, 2021 There has been an increasing emphasis on the need to exploit un- and underexplored environments especially the marine environments for microbial and chemical diversity.
Afegbua, S. L. +4 more
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In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases
eLife, 2021 Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondrial ...
Molly C Sutherland +8 more
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Scientific Reports, 2023 We report here a new application, CustomProteinSearch (CusProSe), whose purpose is to help users to search for proteins of interest based on their domain composition. The application is customizable. It consists of two independent tools, IterHMMBuild and
Leonor Oliveira +6 more
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Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp.
Toxins, 2020 Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM)
Paula M. Moolhuijzen +6 more
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