Results 11 to 20 of about 517,349 (290)

Synthetic Biology of Fungal Natural Products [PDF]

Frontiers in Microbiology, 2015
Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product discovery and production. Until now, different aspects of synthetic biology have been covered in fungal natural product studies from ...
Derek J. Mattern, Derek J. Mattern, Vito eValiante, Shiela E. Unkles, Axel A Brakhage, Axel A Brakhage   +5 more
doaj   +2 more sources

Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Nature Communications, 2021
Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian   +10 more
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Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional Sources of Non-Ribosomal Templated, Large-Target-Spectral, Thermotolerant-Antimicrobial Peptides (by Both), and Iodinin (by EMC)

Pathogens, 2022
Antimicrobial multidrug resistance (MDR) is a global challenge, not only for public health, but also for sustainable agriculture. Antibiotics used in humans should be ruled out for use in veterinary or agricultural settings.
András Fodor, Maxime Gualtieri, Matthias Zeller, Eustachio Tarasco, Michael G. Klein, Andrea M. Fodor, Leroy Haynes, Katalin Lengyel, Steven A. Forst, Ghazala M. Furgani, Levente Karaffa, Tibor Vellai   +11 more
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Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study

Pharmaceutics, 2021
Myxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that belong to class δ-proteobacteria and order Myxococcales. They grow and proliferate by transverse fission under normal conditions, but form fruiting bodies which contain ...
Mudasir Ahmad Bhat, Awdhesh Kumar Mishra, Mujtaba Aamir Bhat, Mohammad Iqbal Banday, Ommer Bashir, Irfan A. Rather, Safikur Rahman, Ali Asghar Shah, Arif Tasleem Jan   +8 more
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Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT By using a detergent-washed membrane preparation, the interaction of the fungal natural product inhibitor aureobasidin A (AbA) with inositol phosphorylceramide synthase (IPC synthase) was studied by kinetic analysis of wild-type and mutant enzyme-catalyzed reactions. AbA inhibited the wild-type enzyme from both
Paul A, Aeed, Casey L, Young, Marek M, Nagiec, Ake P, Elhammer   +3 more
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Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Nature Communications, 2020
Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that ...
Mark J. Calcott, Jeremy G. Owen, David F. Ackerley   +2 more
doaj   +1 more source

NRPSsp: non-ribosomal peptide synthase substrate predictor [PDF]

Bioinformatics, 2011
Abstract Summary: Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity.
Carlos Prieto, Carlos García-Estrada, Diego Lorenzana, Juan Francisco Martín   +3 more
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The genome of the insecticidal Chromobacterium subtsugae PRAA4-1 and its comparison with that of Chromobacterium violaceum ATCC 12472

Genomics Data, 2016
The genome of Chromobacterium subtsugae strain PRAA4-1, a betaproteobacterium producing insecticidal compounds, was sequenced and compared with the genome of C. violaceum ATCC 12472. The genome of C.
Michael B. Blackburn, Michael E. Sparks, Dawn E. Gundersen-Rindal   +2 more
doaj   +1 more source

The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J., Stanley-Wall, Nicola R.; id_orcid, Coulthurst, Sarah J.; id_orcid   +2 more
core   +1 more source

Designing and implementing an assay for the detection of rare and divergent NRPS and PKS clones in European, Antarctic and Cuban soils [PDF]

, 2015
The ever increasing microbial resistome means there is an urgent need for new antibiotics. Metagenomics is an underexploited tool in the field of drug discovery. In this study we aimed to produce a new updated assay for the discovery of biosynthetic gene
David A Pearce, Gregory C A Amos, Gregory C. A. Amos (799040), Leo Calvo-Bado (507757), Berry, Andrew E., Chiara Borsetto (799041), Andrew E Berry, Laskaris, Paris, Calvo-Bado, Leo, Paris Laskaris, Carlos Vallin (5665333), Berry, Andrew, Calvo-Bado, Leo A., David A. Pearce (189743), Leo Calvo-Bado, Elizabeth M H Wellington, Chiara Borsetto, Elizabeth M. H. Wellington (325617), Borsetto, Chiara, Kevin K Newsham, Amos, Gregory, Carlos Vallin, Paris Laskaris (325613), Andrew E. Berry (799043), Martin Krsek, Wellington, Elizabeth M. H., Martin Krsek (799042), Pearce, David, Pearce, David A., Kevin K. Newsham (352778), Vallin, Carlos, Krsek, Martin, Wellington, Elizabeth, Newsham, Kevin, Wellington, E. M. H., Amos, Gregory C. A., Newsham, Kevin K.   +36 more
core   +1 more source