Results 11 to 20 of about 20,368 (260)

Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp.

Toxins, 2020
Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM)
Paula M. Moolhuijzen, Mariano Jordi Muria-Gonzalez, Robert Syme, Catherine Rawlinson, Pao Theen See, Caroline S. Moffat, Simon R. Ellwood   +6 more
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Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Nature Communications, 2021
Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian   +10 more
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Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional Sources of Non-Ribosomal Templated, Large-Target-Spectral, Thermotolerant-Antimicrobial Peptides (by Both), and Iodinin (by EMC)

Pathogens, 2022
Antimicrobial multidrug resistance (MDR) is a global challenge, not only for public health, but also for sustainable agriculture. Antibiotics used in humans should be ruled out for use in veterinary or agricultural settings.
András Fodor, Maxime Gualtieri, Matthias Zeller, Eustachio Tarasco, Michael G. Klein, Andrea M. Fodor, Leroy Haynes, Katalin Lengyel, Steven A. Forst, Ghazala M. Furgani, Levente Karaffa, Tibor Vellai   +11 more
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Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study

Pharmaceutics, 2021
Myxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that belong to class δ-proteobacteria and order Myxococcales. They grow and proliferate by transverse fission under normal conditions, but form fruiting bodies which contain ...
Mudasir Ahmad Bhat, Awdhesh Kumar Mishra, Mujtaba Aamir Bhat, Mohammad Iqbal Banday, Ommer Bashir, Irfan A. Rather, Safikur Rahman, Ali Asghar Shah, Arif Tasleem Jan   +8 more
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Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Nature Communications, 2020
Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that ...
Mark J. Calcott, Jeremy G. Owen, David F. Ackerley   +2 more
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The genome of the insecticidal Chromobacterium subtsugae PRAA4-1 and its comparison with that of Chromobacterium violaceum ATCC 12472

Genomics Data, 2016
The genome of Chromobacterium subtsugae strain PRAA4-1, a betaproteobacterium producing insecticidal compounds, was sequenced and compared with the genome of C. violaceum ATCC 12472. The genome of C.
Michael B. Blackburn, Michael E. Sparks, Dawn E. Gundersen-Rindal   +2 more
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Thermodynamics of apocalmodulin and nitric oxide synthase II peptide interaction [PDF]

FEBS Letters, 2004
The Ca2+‐free form of calmodulin (CaM), apocalmodulin (ApoCaM), regulates a variety of target proteins including nitric oxide synthase II (NOS‐II). The CaM‐binding site of NOS‐II can bind ApoCaM with high affinity. Substitution of hydrophobic amino acids by charged amino acids at crucial positions 3, 9 and 13 within the CaM‐binding motif did not ...
Censarek, Petra, Beyermann, Michael, Koch, Karl-Wilhelm   +2 more
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Modification of soybean sucrose synthase by S-thiolation with ENOD40 peptide A [PDF]

Biochemical and Biophysical Research Communications, 2004
The gene ENOD40 is expressed at an early stage of root nodule organogenesis and has been postulated to play a central regulatory role in the Rhizobium-legume interaction. In vitro translation of soybean ENOD40 mRNA showed that the gene encodes two peptides of 12 and 24aa residues (peptides A and B) that bind to sucrose synthase.
Röhrig, H., John, M., Schmidt, J.
openaire   +3 more sources

Nonribosomal Peptide Synthesis in Animals: The Cyclodipeptide Synthase of Nematostella

Chemistry & Biology, 2011
Cyclodipeptide synthases (CDPSs) are small enzymes structurally related to class-I aminoacyl-tRNA synthetases (aaRSs). They divert aminoacylated tRNAs from their canonical role in ribosomal protein synthesis, for cyclodipeptide formation. All the CDPSs experimentally characterized to date are bacterial.
Seguin, Jérôme, Moutiez, Mireille, Li, Yan, Belin, Pascal, Lecoq, Alain, Fonvielle, Matthieu, Charbonnier, Jean-Baptiste, Pernodet, Jean-Luc, Gondry, Muriel   +8 more
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A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877. [PDF]

PLoS ONE, 2014
The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier protein domains of the polyketide synthases (PKS), non ribosomal peptide synthases (NRPS) and fatty acid synthases (FAS).
Robert Bunet, Ramona Riclea, Luisa Laureti, Laurence Hôtel, Cédric Paris, Jean-Michel Girardet, Dieter Spiteller, Jeroen S Dickschat, Pierre Leblond, Bertrand Aigle   +9 more
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