Results 21 to 30 of about 517,349 (290)

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +2 more sources

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core   +1 more source

A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877. [PDF]

PLoS ONE, 2014
The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier protein domains of the polyketide synthases (PKS), non ribosomal peptide synthases (NRPS) and fatty acid synthases (FAS).
Robert Bunet, Ramona Riclea, Luisa Laureti, Laurence Hôtel, Cédric Paris, Jean-Michel Girardet, Dieter Spiteller, Jeroen S Dickschat, Pierre Leblond, Bertrand Aigle   +9 more
doaj   +1 more source

Suzuki–Miyaura Reaction in the Presence of N-Acetylcysteamine Thioesters Enables Rapid Synthesis of Biomimetic Polyketide Thioester Surrogates for Biosynthetic Studies

Chemistry, 2023
Biomimetic N-acetylcysteamine thioesters are essential for the study of polyketide synthases, non-ribosomal peptide synthetases and fatty acid synthases.
Sebastian Derra, Luca Schlotte, Frank Hahn   +2 more
doaj   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

Bioactivity Screening and Genomic Analysis Reveals Deep-Sea Fish Microbiome Isolates as Sources of Novel Antimicrobials

Marine Drugs, 2023
With the increase in antimicrobial resistance and the subsequent demand for novel therapeutics, the deep-sea fish microbiome can be a relatively untapped source of antimicrobials, including bacteriocins. Previously, bacterial isolates were recovered from
Shona Uniacke-Lowe, Fergus W. J. Collins, Colin Hill, R. Paul Ross   +3 more
doaj   +1 more source

A peptide filtering relation quantifies MHC class I peptide optimization [PDF]

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues [PDF]

, 1994
We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Nguyen, T., Nemer, M., Gerbes, Alexander L., Dagnino, L.   +3 more
core   +2 more sources

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea

New Microbes and New Infections, 2017
We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia, A. Caputo, F. Djossou, D. Raoult   +3 more
doaj   +1 more source

Nonribosomal Peptide Synthesis in Animals: The Cyclodipeptide Synthase of Nematostella

Chemistry & Biology, 2011
Cyclodipeptide synthases (CDPSs) are small enzymes structurally related to class-I aminoacyl-tRNA synthetases (aaRSs). They divert aminoacylated tRNAs from their canonical role in ribosomal protein synthesis, for cyclodipeptide formation. All the CDPSs experimentally characterized to date are bacterial.
Seguin, Jérôme, Moutiez, Mireille, Li, Yan, Belin, Pascal, Lecoq, Alain, Fonvielle, Matthieu, Charbonnier, Jean-Baptiste, Pernodet, Jean-Luc, Gondry, Muriel   +8 more
openaire   +3 more sources