Results 21 to 30 of about 20,368 (260)
Chemistry, 2023 Biomimetic N-acetylcysteamine thioesters are essential for the study of polyketide synthases, non-ribosomal peptide synthetases and fatty acid synthases.
Sebastian Derra +2 more
doaj +1 more source
Molecular biology of natriuretic peptides and nitric oxide synthases [PDF]
Cardiovascular Research, 2001 Natriuretic peptides and nitric oxide play important roles in cardiovascular and renal physiology and disease. The natriuretic peptides - atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide - comprise a family of proteins that participate in the integrated control of intravascular volume and arterial blood pressure ...
openaire +2 more sources
Inhibition of Escherichia coli ATP synthase by amphibian antimicrobial peptides [PDF]
International Journal of Biological Macromolecules, 2010 Previously melittin, the alpha-helical basic honey bee venom peptide, was shown to inhibit F(1)-ATPase by binding at the beta-subunit DELSEED motif of F(1)F(o)-ATP synthase. Herein, we present the inhibitory effects of the basic alpha-helical amphibian antimicrobial peptides, ascaphin-8, aurein 2.2, aurein 2.3, carein 1.8, carein 1.9, citropin 1.1 ...
Laughlin, Thomas F., Ahmad, Zulfiqar
openaire +3 more sources
Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases [PDF]
Nature Communications, 2014 Cyclodipeptide synthases form cyclodipeptides from two aminoacyl transfer RNAs. They use a ping-pong mechanism that begins with transfer of the aminoacyl moiety of the first aminoacyl tRNA onto a conserved serine, yielding an aminoacyl enzyme. Combining X-ray crystallography, site-directed mutagenesis and affinity labelling of the cyclodipeptide ...
Moutiez, Mireille +7 more
openaire +4 more sources
Marine Drugs, 2023 With the increase in antimicrobial resistance and the subsequent demand for novel therapeutics, the deep-sea fish microbiome can be a relatively untapped source of antimicrobials, including bacteriocins. Previously, bacterial isolates were recovered from
Shona Uniacke-Lowe +3 more
doaj +1 more source
Soybean ENOD40 encodes two peptides that bind to sucrose synthase [PDF]
Proceedings of the National Academy of Sciences, 2002 ENOD40 is expressed at an early stage in root nodule organogenesis in legumes. Identification of ENOD40 homologs in nonleguminous plants suggests that this gene may have a more general biological function.
Röhrig, H. +4 more
openaire +3 more sources
New Microbes and New Infections, 2017 We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia +3 more
doaj +1 more source
Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase [PDF]
IUCrJ, 2019 Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. It had previously been hypothesized that the indane ring of indanomycin was formed by the action of IdmH using a Diels–Alder reaction. Here,
Ieva Drulyte +6 more
openaire +8 more sources
Veterinární Medicína, 2008 The osteogenic growth peptide (OGP) regulates the differentiation of marrow mesenchymal stem cells derived from human and rodent cell lines into osteoblasts.
H.B. Zhu +7 more
doaj +1 more source
Antibiotics, 2023 The growing global threat of antimicrobial resistance is reaching a crisis point as common bacterial infections, including those caused by pathogenic Neisseria species, are becoming increasingly untreatable. This is compelling the scientific community to
Elvis Achondou Akomoneh +7 more
doaj +1 more source