Results 41 to 50 of about 517,349 (290)

Inhibition of Escherichia coli ATP synthase by amphibian antimicrobial peptides [PDF]

International Journal of Biological Macromolecules, 2010
Previously melittin, the alpha-helical basic honey bee venom peptide, was shown to inhibit F(1)-ATPase by binding at the beta-subunit DELSEED motif of F(1)F(o)-ATP synthase. Herein, we present the inhibitory effects of the basic alpha-helical amphibian antimicrobial peptides, ascaphin-8, aurein 2.2, aurein 2.3, carein 1.8, carein 1.9, citropin 1.1 ...
Laughlin, Thomas F., Ahmad, Zulfiqar
openaire   +3 more sources

Integrated genomics and proteomics analysis of Paenibacillus peoriae IBSD35 and insights into its antimicrobial characteristics

Scientific Reports, 2022
Antimicrobial resistance has been developing fast and incurring a loss of human life, and there is a need for new antimicrobial agents. Naturally occurring antimicrobial peptides offer the characteristics to counter AMR because the resistance development
Ng Ngashangva, Pulok K. Mukherjee, Chandradev Sharma, Mohan C. Kalita, Indira Sarangthem   +4 more
doaj   +1 more source

Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases [PDF]

Nature Communications, 2014
Cyclodipeptide synthases form cyclodipeptides from two aminoacyl transfer RNAs. They use a ping-pong mechanism that begins with transfer of the aminoacyl moiety of the first aminoacyl tRNA onto a conserved serine, yielding an aminoacyl enzyme. Combining X-ray crystallography, site-directed mutagenesis and affinity labelling of the cyclodipeptide ...
Moutiez, Mireille, Schmitt, Emmanuelle, Seguin, Jérôme, Thai, Robert, Favry, Emmanuel, Belin, Pascal, Mechulam, Yves, Gondry, Muriel   +7 more
openaire   +4 more sources

Soybean ENOD40 encodes two peptides that bind to sucrose synthase [PDF]

Proceedings of the National Academy of Sciences, 2002
ENOD40 is expressed at an early stage in root nodule organogenesis in legumes. Identification of ENOD40 homologs in nonleguminous plants suggests that this gene may have a more general biological function.
Röhrig, H., Schmidt, J., Miklashevichs, E., Schell, J., John, M.   +4 more
openaire   +3 more sources

An Sfp-Type PPTase and Associated Polyketide and Nonribosomal Peptide Synthases in Agrobacterium vitis Are Essential for Induction of Tobacco Hypersensitive Response and Grape Necrosis

Molecular Plant-Microbe Interactions, 2013
An Sfp-type phosphopantetheinyl transferase (PPTase) encoding gene F-avi5813 in Agrobacterium vitis F2/5 was found to be required for the induction of a tobacco hypersensitive response (HR) and grape necrosis.
Desen Zheng, Thomas J. Burr
doaj   +1 more source

Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase [PDF]

IUCrJ, 2019
Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. It had previously been hypothesized that the indane ring of indanomycin was formed by the action of IdmH using a Diels–Alder reaction. Here,
Ieva Drulyte, Jana Obajdin, Chi H. Trinh, Arnout P. Kalverda, Marc W. van der Kamp, Glyn R. Hemsworth, Alan Berry   +6 more
openaire   +8 more sources

Marine Cyanobacteria as Sources of Lead Anticancer Compounds: A Review of Families of Metabolites with Cytotoxic, Antiproliferative, and Antineoplastic Effects

Molecules, 2022
The marine environment is highly diverse, each living creature fighting to establish and proliferate. Among marine organisms, cyanobacteria are astounding secondary metabolite producers representing a wonderful source of biologically active molecules ...
Benjamín Robles-Bañuelos, Lorena María Durán-Riveroll, Edgar Rangel-López, Hugo Isidro Pérez-López, Leticia González-Maya   +4 more
doaj   +1 more source

Albicidin Pathotoxin Produced by Xanthomonas albilineans Is Encoded by Three Large PKS and NRPS Genes Present in a Gene Cluster Also Containing Several Putative Modifying, Regulatory, and Resistance Genes

Molecular Plant-Microbe Interactions, 2004
Xanthomonas albilineans, which causes leaf scald disease of sugarcane, produces a highly potent pathotoxin called albicidin. We report here sequencing and homology analysis of the major gene cluster, XALB1 (55,839 bp), and a second, smaller region, XALB2
Monique Royer, Laurent Costet, Eric Vivien, Martine Bes, Arnaud Cousin, Anne Damais, Isabelle Pieretti, Alexandre Savin, Sandrine Megessier, Magali Viard, Roger Frutos, Dean W. Gabriel, Philippe C. Rott   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source