Results 191 to 200 of about 17,359 (221)

Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication

Microbes and Infection, 2013
Nonsense-mediated mRNA decay (NMD) is an essential and conserved cellular mRNA quality control mechanism. RNA signals to express viral genes from overlapping open reading frames potentially initiate NMD, nevertheless it is not clear whether viral RNAs are sensitive to NMD or if viruses have evolved mechanisms to evade NMD.
Nakano, Kazumi, Ando, Tomomi, Yamagishi, Makoto, Yokoyama, Koichi, Ishida, Takaomi, Ohsugi, Takeo, Tanaka, Yuetsu, Brighty, David W., Watanabe, Toshiki   +8 more
openaire   +3 more sources

Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP−Seq)

2017
Recent progress in the technology of transcriptome-wide high-throughput sequencing has revealed that nonsense-mediated mRNA decay (NMD) targets ~10% of physiologic transcripts for the purpose of tuning gene expression in response to various environmental conditions.
Tatsuaki, Kurosaki, Mainul, Hoque, Lynne E, Maquat   +2 more
openaire   +2 more sources

Nonsense-mediated RNA decay: an emerging modulator of malignancy

Nature Reviews Cancer, 2022
Kun Tan, Miles F Wilkinson
exaly  

The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1

The Nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect the viral genome.
Veronica Nuccetelli, Makram Mghezzi-Habellah, Séverine Deymier, Armelle Roisin, Francine Gerard-Baraggia, Cecilia Rocchi, Pierre-Damien Coureux, Patrice Gouet, Andrea Cimarelli, Vincent Mocquet, Francesca Fiorini   +10 more
openaire   +1 more source

Upregulation of a nonsense mediated decay (NMD) insensitive CFTR mRNA isoform has therapeutic potential for the treatment of 3’ CFTR PTC variants

AbstractBackgroundNonsense or Premature Termination Codon (PTC) mutations of theCFTRgene are pathogenic and found in ∼10% of North American people with cystic fibrosis. PTC mutations induce Nonsense-Mediated mRNA Decay (NMD), leading to a substantial (∼80-90%) reduction in full-length mRNA.
Normand E. Allaire, Mathew Armstrong, Jae Seok Yoon, Priyanka Bhatt, Jan Harrington, Yi Cheng, Hillary Valley, Caitlin Macadino, Hermann Bihler, Andrey Sivachenko, Martin Mense, Calvin Cotton   +11 more
openaire   +1 more source

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

Nature Reviews Molecular Cell Biology, 2019
Tatsuaki Kurosaki, Keita Miyoshi, Lynne E Maquat   +2 more
exaly  

NMD (nonsense-mediated mRNA decay)

2008
openaire   +1 more source

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

Nature Reviews Molecular Cell Biology, 2015
Søren Lykke-Andersen, Torben Heick Jensen   +1 more
exaly  

mRNA Surveillance (nonsense-mediated decay, NMD)

2012
openaire   +1 more source

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

Nature Reviews Molecular Cell Biology, 2004
Lynne E Maquat
exaly