Results 31 to 40 of about 13,282 (244)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Peripeteia in Wonderland: on Translating "Alice"

open access: yesMiędzy Oryginałem a Przekładem, 2017
The article presents Lewis Carroll’s Alice’s Adventures in Wonderland as a classical work within the genre of fantasy, or literature of nonsense. The classification is made according to the “five procedures,” postulated for the genre by the American poet
Elżbieta Tabakowska
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

The nonsense as a hermeneutical problem in the phenomenon of new technologies [PDF]

open access: yesCivilizar, 2010
This article shows how the concept of oblivion of Being (Seinsvergessenheit) developed in the first phase of Heidegger’s work can be applied to its second phase in which he discusses the phenomenon of technique.
Andrea Cortés-Boussac
doaj  

Some uffish thoughts on the Swedish translations of “Jabberwocky”

open access: yesThe European Journal of Humour Research, 2017
In this article the “translatability” (and/or untranslatability) of nonsense is addressed. For this purpose, five Swedish versions of Lewis Carroll’s nonsense poem “Jabberwocky” from Lewis Carroll’s Through the Looking-Glass (1871) are examined: the ...
Björn Sundmark
doaj   +3 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

open access: yesFEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi   +4 more
wiley   +1 more source

Between the Joys of Nonsense and the Excess of the Other: Foodways in Laura E. Richards’s Children’s Poems

open access: yesEuropean Journal of American Studies
Food and eating are recurring themes throughout Laura Richards’s children’s poems. This essay examines how several of Richards’s poems bring together food and education, specifically in conjunction with excess, grotesquerie, and otherness.
Antonia Purk
doaj   +1 more source

Nonsense of the existence and the 'sense' of the absurdity: Congenialities of Albert Camus' and Petar Sarić's creative proceeds [PDF]

open access: yesBaština, 2013
The philosophy of existentialism achieved its greatest impact through Sartre's lectures Existentialism is Humanity. His philosophy, founded on the thesis on the tragic throw in the whirlpool of the existence, had great impact on the literary achievements
Jeftimijević-Mihajlović Marija
doaj  

A Novel Mutation of PARK-2 Gene in a Patient with Early-onset Parkinson’s Disease

open access: yesOman Medical Journal, 2020
Between 3–5% of all patients with Parkinson’s disease (PD) have onset before the age of 40 years, which is likely related to genetic causes. Parkin gene mutations are the most common mutations, which are associated with autosomal recessive early-onset PD.
Tariq Alafifi   +4 more
doaj   +1 more source

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