Results 31 to 40 of about 2,217 (170)

Are CB₁ receptor antagonists nootropic or cognitive impairing agents? [PDF]

Drug Development Research, 2009
AbstractFor more than a decade, a considerable amount of research has examined the effects of rimonabant (SR 141716) and other CB1 receptor antagonists in both in vivo and in vitro models of learning and memory. In addition to its utility in determining whether the effects of drugs are mediated though a CB1 receptor mechanism of action, these ...
Stephen A, Varvel, Laura E, Wise, Aron H, Lichtman   +2 more
openaire   +2 more sources

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Exposure definitions in real‐world pregnancy studies vary across studies, data sources, treatments and outcomes, yet their impact on prevalence estimates remains unexamined. Objectives To identify the most used exposure definitions during the 1st trimester and evaluate their impact on prevalence estimates: Methods We reviewed 400 ...
Gabra Nohmie, Anick Bérard, Anton Pottegård, Mette Bliddal   +3 more
wiley   +1 more source

Cognitive impairments in cerebrovascular disease: What is between health and dementia?

Неврология, нейропсихиатрия, психосоматика, 2015
The problem of cerebrovascular lesions takes on even greater significance with the higher prevalence of both acute and chronic forms of cerebrovascular diseases (CVD).
A. Yu. Emelin
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

In Search of Genetic Agency: On the Uses and Actionability of Direct‐to‐Consumer Genetic Test Results in Biohacking Practices

Sociology of Health &Illness, Volume 48, Issue 6, July 2026.
ABSTRACT The article examines why and with what consequences biohacking individuals use direct‐to‐consumer genetic tests (DTC GTs). Based on thematic coding of 15 semi‐structured interviews, it argues that these users generally see themselves as capable of generating actionable knowledge to optimise future health by manipulating their ‘milieu’. DTC GTs
Carsten Stage
wiley   +1 more source

Borates in Biomedicine: A Retrospective Analysis

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
The graphical abstract displays the molecular structure of boric acid, an hormetic substance with pleiotropic bioactivity. Complementing previous studies describing the use of organoboron compounds as potent therapeutics for use in anticancer, antimicrobial, antiparasitic, and related other pharmaceutical uses, this study focuses on the emerging ...
Mario Pagliaro, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna   +3 more
wiley   +1 more source

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise

Frontiers in Pharmacology, 2018
Asiatic acid (AA) is a naturally occurring aglycone of ursane type pentacyclic triterpenoids. It is abundantly present in many edible and medicinal plants including Centella asiatica that is a reputed herb in many traditional medicine formulations for ...
Mohamed Fizur Nagoor Meeran, Sameer N. Goyal, Kapil Suchal, Charu Sharma, Chandragouda R. Patil, Shreesh K. Ojha   +5 more
doaj   +1 more source

Nootropic Agents Enhance the Recruitment of Fast GABAA Inhibition in Rat Neocortex [PDF]

Cerebral Cortex, 2004
It is widely believed that nootropic (cognition-enhancing) agents produce their therapeutic effects by augmenting excitatory synaptic transmission in cortical circuits, primarily through positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors (AMPARs).
Douglas S F, Ling, Larry S, Benardo
openaire   +2 more sources

Interaction of vitamin D, homocystein and dental diseases

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The 1,2,4-triazole nucleus is resistant to metabolism and is an important pharmacophore; it can increase solubility and improve the pharmacokinetic and pharmacodynamic profile of drugs.
Ye. O. Karpun , Yu. V. Karpenko, M. V. Parchenko, O. A. Bihdan   +3 more
doaj   +1 more source